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Pregled bibliografske jedinice broj: 1096301

Quantitative analysis of galectin-3 expression in benign and malignant thyroid nodules


Šamija, Ivan; Mateša, Neven; Tadinac, Sanja; Jukić, Tomislav
Quantitative analysis of galectin-3 expression in benign and malignant thyroid nodules // Acta clinica Croatica, 59 (2020), 25-31 doi:10.20471/acc.2020.59.s1.03 (recenziran, članak, znanstveni)


CROSBI ID: 1096301 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Quantitative analysis of galectin-3 expression in benign and malignant thyroid nodules

Autori
Šamija, Ivan ; Mateša, Neven ; Tadinac, Sanja ; Jukić, Tomislav

Izvornik
Acta clinica Croatica (0353-9466) 59 (2020); 25-31

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
thyroid nodule ; reverse transcriptase polymerase chain reaction ; galectin-3 ; thyroid neoplasms ; fine-needle biopsy

Sažetak
In this study, galectin-3 was analyzed as a potential marker for preoperative detection of malignant thyroid lesions. Galectin-3 expression was analyzed by quantitative real-time reverse transcription polymerase chain reaction (RT -PCR) in preoperative thyroid fine-needle aspirates from 245 patients with thyroid nodules. Out of 245 samples, 238 were adequate for analysis by RT - PCR. Galectin-3 was positive in 34 (89.5%) of 38 papillary carcinomas, 3 (89.5%) of 4 follicular carcinomas, 17 (53.1%) of 32 follicular adenomas, 2 (33.3%) of 6 Hurthle cell adenoma, 11 (28.2%) of 39 Hashimoto thyroiditis, and 69 (57.9%) of 119 nodular goiter samples. Galectin-3 showed specificity of 49.5%, sensitivity of 88.1%, positive predictive value of 27.2%, and negative predictive value of 95.1% as a marker for detection of malignant thyroid nodules. Owing to the relatively low positive predictive value due to the relatively high false positive rate, the clinical value of galectin-3 analyzed by quantitative real-time RT -PCR as a marker for preoperative detection of malignant thyroid lesions is limited.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Stomatološki fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Tomislav Jukić (autor)

Avatar Url Neven Mateša (autor)

Avatar Url Ivan Šamija (autor)

Avatar Url Tomislav Jukić (autor)

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Šamija, Ivan; Mateša, Neven; Tadinac, Sanja; Jukić, Tomislav
Quantitative analysis of galectin-3 expression in benign and malignant thyroid nodules // Acta clinica Croatica, 59 (2020), 25-31 doi:10.20471/acc.2020.59.s1.03 (recenziran, članak, znanstveni)
Šamija, I., Mateša, N., Tadinac, S. & Jukić, T. (2020) Quantitative analysis of galectin-3 expression in benign and malignant thyroid nodules. Acta clinica Croatica, 59, 25-31 doi:10.20471/acc.2020.59.s1.03.
@article{article, author = {\v{S}amija, Ivan and Mate\v{s}a, Neven and Tadinac, Sanja and Juki\'{c}, Tomislav}, year = {2020}, pages = {25-31}, DOI = {10.20471/acc.2020.59.s1.03}, keywords = {thyroid nodule, reverse transcriptase polymerase chain reaction, galectin-3, thyroid neoplasms, fine-needle biopsy}, journal = {Acta clinica Croatica}, doi = {10.20471/acc.2020.59.s1.03}, volume = {59}, issn = {0353-9466}, title = {Quantitative analysis of galectin-3 expression in benign and malignant thyroid nodules}, keyword = {thyroid nodule, reverse transcriptase polymerase chain reaction, galectin-3, thyroid neoplasms, fine-needle biopsy} }
@article{article, author = {\v{S}amija, Ivan and Mate\v{s}a, Neven and Tadinac, Sanja and Juki\'{c}, Tomislav}, year = {2020}, pages = {25-31}, DOI = {10.20471/acc.2020.59.s1.03}, keywords = {thyroid nodule, reverse transcriptase polymerase chain reaction, galectin-3, thyroid neoplasms, fine-needle biopsy}, journal = {Acta clinica Croatica}, doi = {10.20471/acc.2020.59.s1.03}, volume = {59}, issn = {0353-9466}, title = {Quantitative analysis of galectin-3 expression in benign and malignant thyroid nodules}, keyword = {thyroid nodule, reverse transcriptase polymerase chain reaction, galectin-3, thyroid neoplasms, fine-needle biopsy} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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