The association between prolactin concentration and aggression in female patients with schizophrenia (CROSBI ID 286506)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Puljić, Krešimir ; Herceg, Miroslav ; Tudor, Lucija ; Pivac, Nela
engleski
The association between prolactin concentration and aggression in female patients with schizophrenia
Objectives: This study assessed the association between serum prolactin (PRL) concentration and aggression in female patients with schizophrenia. Methods: Female patients with schizophrenia (N = 120) were diagnosed using SCID-5 based on the DSM-5 criteria. They were sampled at the University Psychiatric Hospital Vrapce during the period from March 2017 to March 2019. Aggression was evaluated using the Positive and Negative Syndrome Scale (PANSS), and Overt Aggression Scale (OAS). Patients were subdivided into aggressive and non-aggressive groups. PRL was determined in serum using electrochemiluminescence (ECLIA) method. Results: Aggressive patients with schizophrenia had significantly (p < 0.0001) increased PRL concentration compared to non-aggressive patients. Higher PRL concentration was significantly (p < 0.0001) associated with pronounced aggressive symptoms determined by the OAS scores. When patients were subdivided into those who were treated with risperidone, haloperidol, paliperidone, amisulpride, and a group that was not treated with these antipsychotics, aggressive patients in both groups had significantly higher PRL concentrations than non-aggressive patients. Higher antipsychotic dose was related to increased PRL concentration (p = 0.004). Conclusions: Our findings suggest that higher PRL is significantly associated with aggression, irrespective of the antipsychotic medication, in female patients with schizophrenia.
Prolactin ; aggression ; antipsychotic medication ; hyperprolactinaemia ; schizophrenia
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
22 (4)
2020.
301-309
objavljeno
1562-2975
1814-1412
10.1080/15622975.2020.1795254
Povezanost rada
Temeljne medicinske znanosti