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Pregled bibliografske jedinice broj: 1095178

Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters


Hlapčić, Iva; Belamarić, Daniela; Bosnar, Martina; Kifer, Domagoj; Vukić Dugac, Andrea; Rumora, Lada
Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters // Diagnostics, 10 (2020), 1029, 15 doi:10.3390/diagnostics10121029 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1095178 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters

Autori
Hlapčić, Iva ; Belamarić, Daniela ; Bosnar, Martina ; Kifer, Domagoj ; Vukić Dugac, Andrea ; Rumora, Lada

Izvornik
Diagnostics (2075-4418) 10 (2020); 1029, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic obstructive pulmonary disease ; cytokines ; systemic inflammation ; clusters ; adenosine triphosphate ; heat shock protein 70

Sažetak
Interleukin (IL)-1α, IL-1β, IL-6, IL-8 and tumor necrosis factor (TNF)α contribute to inflammation in chronic obstructive pulmonary disease (COPD). We wanted to investigate their interrelations and association with disease severity, as well as to combine them with other inflammation-associated biomarkers and evaluate their predictive value and potential in identifying various patterns of systemic inflammation. One hundred and nine patients with stable COPD and 95 age- and sex-matched controls were enrolled in the study. Cytokines’ concentrations were determined in plasma samples by antibody-based multiplex immunosorbent assay kits. Investigated cytokines were increased in COPD patients but were not associated with disease or symptoms severity. IL-1β, IL-6 and TNFα showed the best discriminative values regarding ongoing inflammation in COPD. Inflammatory patterns were observed in COPD patients when cytokines, C-reactive protein (CRP), fibrinogen (Fbg), extracellular adenosine triphosphate (eATP), extracellular heat shock protein 70 (eHsp70) and clinical data were included in cluster analysis. IL-1β, eATP and eHsp70 combined correctly classified 91% of cases. Therefore, due to the heterogeneity of COPD, its assessment could be improved by combination of biomarkers. Models including IL-1β, eATP and eHsp70 might identify COPD patients, while IL-1β, IL-6 and TNFα combined with CRP, Fbg, eATP and eHsp70 might be informative regarding various COPD clinical subgroups.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
IP-2014-09-1247 - Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti (Hsp70COPD) (HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za plućne bolesti "Jordanovac",
Klinički bolnički centar Zagreb,
Fidelta d.o.o.

Citiraj ovu publikaciju

Hlapčić, Iva; Belamarić, Daniela; Bosnar, Martina; Kifer, Domagoj; Vukić Dugac, Andrea; Rumora, Lada
Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters // Diagnostics, 10 (2020), 1029, 15 doi:10.3390/diagnostics10121029 (međunarodna recenzija, članak, znanstveni)
Hlapčić, I., Belamarić, D., Bosnar, M., Kifer, D., Vukić Dugac, A. & Rumora, L. (2020) Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters. Diagnostics, 10, 1029, 15 doi:10.3390/diagnostics10121029.
@article{article, year = {2020}, pages = {15}, DOI = {10.3390/diagnostics10121029}, chapter = {1029}, keywords = {chronic obstructive pulmonary disease, cytokines, systemic inflammation, clusters, adenosine triphosphate, heat shock protein 70}, journal = {Diagnostics}, doi = {10.3390/diagnostics10121029}, volume = {10}, issn = {2075-4418}, title = {Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters}, keyword = {chronic obstructive pulmonary disease, cytokines, systemic inflammation, clusters, adenosine triphosphate, heat shock protein 70}, chapternumber = {1029} }
@article{article, year = {2020}, pages = {15}, DOI = {10.3390/diagnostics10121029}, chapter = {1029}, keywords = {chronic obstructive pulmonary disease, cytokines, systemic inflammation, clusters, adenosine triphosphate, heat shock protein 70}, journal = {Diagnostics}, doi = {10.3390/diagnostics10121029}, volume = {10}, issn = {2075-4418}, title = {Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters}, keyword = {chronic obstructive pulmonary disease, cytokines, systemic inflammation, clusters, adenosine triphosphate, heat shock protein 70}, chapternumber = {1029} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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