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Pregled bibliografske jedinice broj: 1094714

Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury


Dolenec, Petra; Pilipović, Kristina; Janković, Tamara; Župan, Gordana
Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury // Journal of neuropathology and experimental neurology, 79 (2020), 11; 1163-1182 doi:10.1093/jnen/nlaa111 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1094714 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury

Autori
Dolenec, Petra ; Pilipović, Kristina ; Janković, Tamara ; Župan, Gordana

Izvornik
Journal of neuropathology and experimental neurology (0022-3069) 79 (2020), 11; 1163-1182

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cerebellum ; Neurodegeneration ; Neuroglia ; Rat ; Synapses ; Traumatic brain injury

Sažetak
We examined damage and repair processes in the rat cerebellum within the first week following moderate traumatic brain injury (TBI) induced by lateral fluid percussion injury (LFPI) over the left parietal cortex. Rats were killed 1, 3, or 7 days after the injury or sham procedure. Fluoro-Jade B staining revealed 2 phases of neurodegenerative changes in the cell bodies and fibers: first, more focal, 1 day after the LFPI, and second, widespread, starting on post-injury day 3. Purkinje cell loss was detected in posterior lobule IX 1 day following LFPI. Apoptosis was observed in the cerebellar cortex, on days 1 and 7 following LFPI, and was not caspase- or apoptosis- inducing factor (AIF)-mediated. AIF immunostaining indicated axonal damage in the cerebellar white matter tracts 3- and 7-days post-injury. Significant astrocytosis and microgliosis were noticed on day 7 following LFPI at the sites of neuronal damage and loss. Immunohistochemical labeling with the presynaptic markers synaptophysin and growth- associated protein-43 revealed synaptic perturbations already on day 1 that were more pronounced at later time points following LFPI. These results provide new insights into pathophysiological alterations in the cerebellum and their mechanisms following cerebral TBI.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka

doi

Citiraj ovu publikaciju

Dolenec, Petra; Pilipović, Kristina; Janković, Tamara; Župan, Gordana
Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury // Journal of neuropathology and experimental neurology, 79 (2020), 11; 1163-1182 doi:10.1093/jnen/nlaa111 (međunarodna recenzija, članak, znanstveni)
Dolenec, P., Pilipović, K., Janković, T. & Župan, G. (2020) Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury. Journal of neuropathology and experimental neurology, 79 (11), 1163-1182 doi:10.1093/jnen/nlaa111.
@article{article, year = {2020}, pages = {1163-1182}, DOI = {10.1093/jnen/nlaa111}, keywords = {Cerebellum, Neurodegeneration, Neuroglia, Rat, Synapses, Traumatic brain injury}, journal = {Journal of neuropathology and experimental neurology}, doi = {10.1093/jnen/nlaa111}, volume = {79}, number = {11}, issn = {0022-3069}, title = {Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury}, keyword = {Cerebellum, Neurodegeneration, Neuroglia, Rat, Synapses, Traumatic brain injury} }
@article{article, year = {2020}, pages = {1163-1182}, DOI = {10.1093/jnen/nlaa111}, keywords = {Cerebellum, Neurodegeneration, Neuroglia, Rat, Synapses, Traumatic brain injury}, journal = {Journal of neuropathology and experimental neurology}, doi = {10.1093/jnen/nlaa111}, volume = {79}, number = {11}, issn = {0022-3069}, title = {Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury}, keyword = {Cerebellum, Neurodegeneration, Neuroglia, Rat, Synapses, Traumatic brain injury} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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