A case of an unusual lineage switch in late relapse ALL—is it actually a secondary leukemia? (CROSBI ID 286241)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Babić, Antonija ; Kurić, Lejla ; Dubravčić, Klara ; Perić, Zinaida ; Batinić, Josip ; Armanda, Višnja ; Kuljiš, Dubravka ; Batinić, Drago
engleski
A case of an unusual lineage switch in late relapse ALL—is it actually a secondary leukemia?
Acute lymphoblastic leukemia (ALL) is a malignant disease of lymphoid precursors. According to immunophenotype, it is further subdivided into precursor B cell ALL and precursor T cell ALL, with precursor B cell ALL being much more common both in children and adults. Lineage switch from one lymphoid lineage to another during the course of the disease is extremely rarely reported. Here, we describe a case of a child who initially presented as a precursor B-ALL but 15 years later and after two successfully treated relapses of the original ALL presented with early T cell precursor leukemia. Although it was considered as a relapse, it could be interpreted as a case of secondary leukemia, which can be explained as a consequence of treatment as well as a constitutional feature of an individual. Also, it draws attention to the possibility that hematopoietic cells, and in that context also leukemic cells, are much more plastic and capable of reprogramming than previously thought.
Acute lymphoblastic leukemia ; Secondary leukemia ; Lineage switch
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Podaci o izdanju
13 (1)
2019.
51-55
objavljeno
1868-9256
1865-5785
10.1007/s12308-019-00371-x
Povezanost rada
Kliničke medicinske znanosti