engleski

The relationship between COMT polymorphism, parenting behaviour and problem behaviors: a prospective study

Both genetic (i.e., Catechol-O-methyltransferase Val158Met/COMT-rs4680) and environmental factors (e.g., negative parenting practices including authoritarian and permissive parenting styles) have been implicated as vulnerability factors for future problem behaviors. The present study examined the susceptibility properties of COMT genotype to adverse and favorable parenting styles in relation to childhood problem behaviors. The sample was composed of community children (N = 175 ; 80 boys ; T1age=6.98 ; T2age=9.78) and their parents chosen through a multistage stage random sampling procedure. At T1, children were genotyped for COMT-rs4680, whereas parents rated their parenting styles. DNA was extracted from buccal swabs and genotyped using TaqmanTM SNP genotyping assay on Applied Biosystems™ 7500 Real-Time PCR System. At T2, teachers rated children’s problem behaviors. As in previous studies, we divided the sample into those with the high-activity Val/Val genotype (20.9%) and those with 1 or more Met alleles (79.1%). The results showed no main effects of gender and COMT on teacher-rated problem behaviors. Main effects of all three parenting styles: children with authoritarian and permissive parents were rated as exhibiting more problem behaviors by their teachers, whereas authoritative parenting was related to less conduct problems. There is also a significant interactive effect between authoritarian parenting and COMT rs4680 genotype.

COMT polymorphism, parenting behaviour, problem behaviors

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