engleski

The Impact of the Vitamins in the Prevention of Gastroesophageal Reflux Disease, Barrett\'s Oesophagus and Oesophageal Adenocarcinoma

INTRODUCTION Antioxidant micronutrients are a heterogeneous group of different molecules (vitamins A, C and E, coenzyme Q, glucose, ubiquinon, bilirubine, urates, flavonoids, some amino-acids and certain peptides) which have in common a functional possibility for the binding of oxygen radicals. Previous studies have shown that the antioxidants through their binding with the oxidants could prevent cell deterioration and cancer development. This study evaluated the impact of vitamins A, C and E intake in the prevention of gastroesophageal reflux disease (GERD), Barrett's oesophagus (BE), and oesophageal adenocarcinoma (EADC). METHODOLOGY There were 180 subjects included in the study, 109 males and 71 females, which were divided in the four groups (70 patients with GERD, 20 patients with BE, 20 patients with EADC, and 70 healthy examinees composing a control group). Their antioxidant vitamins intake was investigated through the usage of the dietary questionnaires. Concentration of the mentioned antioxidant vitamins in serum was detected by HPLC method. RESULTS AND DISCUSSION The results showed that the healthy examinees had consumed the greater quantities of the vitamins A, C and E, through both the natural (fruits and vegetables) and the supplementary (industrial vitamin additives) way, than the patients with GERD, BE and EADC. This was reflected in the higher serum levels of the mentioned vitamins in the control group in the comparison with the other groups. The Fischer's exact test has showed that all the differences were statistically significant with p<0.001. CONCLUSIONS Based on this, the consummation of vitamins A, C and E through both the natural (fruits and vegetables) and the supplementary (industrial vitamin additives) ways could be advised in order to prevent the development of GERD, BE and EADC in a healthy population on one hand, and to improve the life quality of the patients with the mentioned diseases on the other hand.

antioxidant vitamins ; dietary questionnaire ; gastroesophageal reflux disease ; Barrett's oesophagus ; oesophageal adenocarcinoma

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