engleski

INNATE-LIKE LYMPHOID T CELLS IN PSORIASIS: CLUES ON IMMUNOPHENOTYPE, TRANSCRIPTOME AND TCR REPERTOIRE

Innate-like, MR1-restricted and γδ T cells are vital for maintaining homeostatic functions at barrier sites, but their regulation in psoriasis (PV), an autoinflammatory skin disease, is not well understood. Here, we identify an MR1- restricted CD4+CD8±TCRVα7.2+ T cell population, akin to mucosal-associated innate- like T (MAIT) cells, which is contracted in the blood of male patients, and track the sources of heterogeneity among circulating γδ T cells by identifying distinct γδint and γδhigh subsets that exhibit differential perturbations in relation to sex-disaggregated case-control status, serum content of skin-homing cytokines, and CMV exposure. In this context, transcriptional alterations of FACS-purified MR1+ and ydTCR+ T cells will be discussed, together with updated estimates of Vδ1 and Vδ2 T cell subcommunities in psoriasis. Future avenues for T cell receptor (TCR) clonality research using next-generation sequencing will be presented as well.

MR1, mucosal associated invariant T cells, γδ T lymphocytes, psoriasis

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