engleski

Halohydrin dehalogenases and their potential in industrial application – a viewpoint of enzyme reaction engineering

At the moment, there are approx. 100 published papers investigating halohydrin dehalogenases from different aspects ; enzymology, molecular biology and reactions they can catalyse. Unquestionably, these enzymes are of great importance and hold an immense potential due to the wide spectrum of different compounds that can be synthesized by their action. These compounds, such as chiral epoxides, β- substituted alcohols, oxazolidinones etc., significantly enrich the chemist’s toolbox and, moreover, open the possibility for the synthesis of even more complex compounds. Still, there are many unknowns, and it is the purpose of this work to demonstrate the possibilities and bottlenecks, in scientific sense, that could further help in broadening the applicative potential of these fascinating enzymes.

halohydrin dehalogenases ; process metrics ; epoxides ; enzyme kinetics ; chiral molecules

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