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Pregled bibliografske jedinice broj: 1090418

Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma


Sreter, Katherina B.; Popovic-Grle, Sanja; Lampalo, Marina; Konjevod, Marcela; Tudor, Lucija; Nikolac Perkovic, Matea; Jukic, Irena; Bingulac-Popovic, Jasna; Safic Stanic, Hana; Markeljevic, Jasenka et al.
Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma // Journal of Personalized Medicine, 10 (2020), 4; 189, 20 doi:10.3390/jpm10040189 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1090418 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma

Autori
Sreter, Katherina B. ; Popovic-Grle, Sanja ; Lampalo, Marina ; Konjevod, Marcela ; Tudor, Lucija ; Nikolac Perkovic, Matea ; Jukic, Irena ; Bingulac-Popovic, Jasna ; Safic Stanic, Hana ; Markeljevic, Jasenka ; Pivac, Nela ; Svob Strac, Dubravka

Izvornik
Journal of Personalized Medicine (2075-4426) 10 (2020), 4; 189, 20

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
asthma ; plasma BDNF concentration ; BDNF and NTRK2 (TrkB gene) polymorphisms ; severity ; phenotypes ; aspirin

Sažetak
Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning and immune responses ; however, their role in asthma remains unclear. Plasma BDNF concentrations, as well as BDNF and NTRK2 (TrkB gene) polymorphisms, were investigated in 120 asthma patients and 120 healthy individuals using enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. The genotype and allele frequencies of BDNF Val66Met (rs6265) and NTRK2 rs1439050 polymorphisms did not differ between healthy individuals and asthma patients, nor between patients grouped according to severity or different asthma phenotypes. Although plasma BDNF concentrations were higher among healthy subjects carrying the BDNF Val66Met GG genotype compared to the A allele carriers, such differences were not detected in asthma patients, suggesting the influences of other factors. Plasma BDNF concentration was not affected by NTRK2 rs1439050 polymorphism. Asthma patients had higher plasma BDNF concentrations than control subjects ; however, no differences were found between patients subdivided according to asthma severity, or Type-2, allergic, and eosinophilic asthma. Higher plasma BDNF levels were observed in asthma patients with aspirin sensitivity and aspirin-exacerbated respiratory disease. These results suggest that plasma BDNF may serve as a potential peripheral biomarker for asthma, particularly asthma with aspirin sensitivity.

Znanstvena područja
Interdisciplinarne biotehničke znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Hrvatski zavod za transfuzijsku medicinu

Citiraj ovu publikaciju

Sreter, Katherina B.; Popovic-Grle, Sanja; Lampalo, Marina; Konjevod, Marcela; Tudor, Lucija; Nikolac Perkovic, Matea; Jukic, Irena; Bingulac-Popovic, Jasna; Safic Stanic, Hana; Markeljevic, Jasenka et al.
Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma // Journal of Personalized Medicine, 10 (2020), 4; 189, 20 doi:10.3390/jpm10040189 (međunarodna recenzija, članak, znanstveni)
Sreter, K., Popovic-Grle, S., Lampalo, M., Konjevod, M., Tudor, L., Nikolac Perkovic, M., Jukic, I., Bingulac-Popovic, J., Safic Stanic, H. & Markeljevic, J. (2020) Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma. Journal of Personalized Medicine, 10 (4), 189, 20 doi:10.3390/jpm10040189.
@article{article, year = {2020}, pages = {20}, DOI = {10.3390/jpm10040189}, chapter = {189}, keywords = {asthma, plasma BDNF concentration, BDNF and NTRK2 (TrkB gene) polymorphisms, severity, phenotypes, aspirin}, journal = {Journal of Personalized Medicine}, doi = {10.3390/jpm10040189}, volume = {10}, number = {4}, issn = {2075-4426}, title = {Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma}, keyword = {asthma, plasma BDNF concentration, BDNF and NTRK2 (TrkB gene) polymorphisms, severity, phenotypes, aspirin}, chapternumber = {189} }
@article{article, year = {2020}, pages = {20}, DOI = {10.3390/jpm10040189}, chapter = {189}, keywords = {asthma, plasma BDNF concentration, BDNF and NTRK2 (TrkB gene) polymorphisms, severity, phenotypes, aspirin}, journal = {Journal of Personalized Medicine}, doi = {10.3390/jpm10040189}, volume = {10}, number = {4}, issn = {2075-4426}, title = {Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma}, keyword = {asthma, plasma BDNF concentration, BDNF and NTRK2 (TrkB gene) polymorphisms, severity, phenotypes, aspirin}, chapternumber = {189} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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