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Pregled bibliografske jedinice broj: 1090204

Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease


Markelić, Ivona; Hlapčić, Iva; Rogić, Dunja; Rako, Ivana; Samaržija, Miroslav; Popović-Grle, Sanja; Rumora, Lada; Vukić Dugac, Andrea
Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease // Nutrition metabolism and cardiovascular diseases, 30 (2020), 1-9 doi:10.1016/j.numecd.2020.07.039 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1090204 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease

Autori
Markelić, Ivona ; Hlapčić, Iva ; Rogić, Dunja ; Rako, Ivana ; Samaržija, Miroslav ; Popović-Grle, Sanja ; Rumora, Lada ; Vukić Dugac, Andrea

Izvornik
Nutrition metabolism and cardiovascular diseases (0939-4753) 30 (2020); 1-9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COPD ; dyslipidaemia ; lipid parameters ; MHR ; comorbidity ; therapy

Sažetak
Background and Aims: Limited number of studies investigated lipid profile in chronic obstructive pulmonary disease (COPD) with inconsistent results. This study aimed to investigate lipid parameters in sera of patients with stable COPD and their associations with disease severity, smoking, comorbidities and therapy. Methods and Results: The study included 137 COPD patients and 95 controls. Triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were assessed. Non-HDL-C (NHC), atherogenic coefficient (AC), TG/HDL-C, atherogenic index of plasma (AIP), Castelli's risk index I and II (CRI-I, CRI-II), and monocyte to HDL ratio (MHR) were calculated. HDL-C and MHR were increased, while other lipid parameters and indices were decreased in COPD patients compared to healthy individuals. Smoking did not influence lipid parameters. However, lipid profile was altered only in more severe disease stages. AC, CRI-I and CRI-II showed positive association with lung function parameters in COPD patients, and negative with COPD multicomponent indices (ADO, BODCAT, BODEx, CODEx and DOSE). Combined model that included CRI-II, C-reactive protein, fibrinogen and white blood cells showed great diagnostic performances, and correctly classified 72% of study participants with an AUC of 0.800 (0.742 - 0.849), P < 0.001. Bronchodilator monotherapy and statins have opposite impact on TC, LDL-C and NHC, while TG, TG/HDL-C and AIP were increased in COPD patients with cardiovascular diseases. Conclusion: Lipid disbalance is present in COPD, and it seems to occur later as the disease progresses. Further studies are needed to illuminate the underlying mechanism of dyslipidaemia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
IP-2014-09-1247 - Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti (Hsp70COPD) (HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za plućne bolesti "Jordanovac",
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Markelić, Ivona; Hlapčić, Iva; Rogić, Dunja; Rako, Ivana; Samaržija, Miroslav; Popović-Grle, Sanja; Rumora, Lada; Vukić Dugac, Andrea
Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease // Nutrition metabolism and cardiovascular diseases, 30 (2020), 1-9 doi:10.1016/j.numecd.2020.07.039 (međunarodna recenzija, članak, znanstveni)
Markelić, I., Hlapčić, I., Rogić, D., Rako, I., Samaržija, M., Popović-Grle, S., Rumora, L. & Vukić Dugac, A. (2020) Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease. Nutrition metabolism and cardiovascular diseases, 30, 1-9 doi:10.1016/j.numecd.2020.07.039.
@article{article, year = {2020}, pages = {1-9}, DOI = {10.1016/j.numecd.2020.07.039}, keywords = {COPD, dyslipidaemia, lipid parameters, MHR, comorbidity, therapy}, journal = {Nutrition metabolism and cardiovascular diseases}, doi = {10.1016/j.numecd.2020.07.039}, volume = {30}, issn = {0939-4753}, title = {Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease}, keyword = {COPD, dyslipidaemia, lipid parameters, MHR, comorbidity, therapy} }
@article{article, year = {2020}, pages = {1-9}, DOI = {10.1016/j.numecd.2020.07.039}, keywords = {COPD, dyslipidaemia, lipid parameters, MHR, comorbidity, therapy}, journal = {Nutrition metabolism and cardiovascular diseases}, doi = {10.1016/j.numecd.2020.07.039}, volume = {30}, issn = {0939-4753}, title = {Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease}, keyword = {COPD, dyslipidaemia, lipid parameters, MHR, comorbidity, therapy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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