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Pregled bibliografske jedinice broj: 1090199

Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: potential biomarkers in multicomponent models comprising IL-1beta


Rumora, Lada; Hlapčić, Iva; Popović-Grle, Sanja; Rako, Ivana; Rogić, Dunja; Čepelak, Ivana
Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: potential biomarkers in multicomponent models comprising IL-1beta // PLoS One, 15 (2020), 6; e0234363-e0234363 doi:10.1371/journal.pone.0234363 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1090199 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: potential biomarkers in multicomponent models comprising IL-1beta

Autori
Rumora, Lada ; Hlapčić, Iva ; Popović-Grle, Sanja ; Rako, Ivana ; Rogić, Dunja ; Čepelak, Ivana

Izvornik
PLoS One (1932-6203) 15 (2020), 6; E0234363-e0234363

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic obstructive pulmonary disease ; uric acid ; uric acid to creatinine ratio ; interleukin 1beta ; inflammasome

Sažetak
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, with oxidative stress and inflammation implicated in its development. Uric acid (UA) could exert anti-oxidative, pro-oxidative or pro-inflammatory effects, depending on the specific context. It was recently shown that soluble UA, and not just its crystals, could activate the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to interleukin (IL)-1β secretion. Objectives: We aimed to assess the differences in blood levels of UA and its ratio with creatinine (UCR) between COPD patients and healthy subjects, as well as their association with disease severity, smoking status, common COPD comorbidities and therapy regimes. The diagnostic characteristics of UA and UCR were also explored. Participants and methods: This study included 109 stable COPD patients and 95 controls and measured white blood cells (WBC), C-reactive protein (CRP), fibrinogen (Fbg), IL-1β, creatinine (CREAT) and UA. Results: All of the parameters were increased in COPD patients, except for CREAT. UA and UCR were positively associated with WBC, CRP and IL-1β. COPD smokers had lower UA and UCR values. Common COPD therapy did not affect UA or UCR, while patients with cardiovascular diseases (CVD) had higher UA, but not UCR, levels. Patients with higher UCR values showed worse disease-related outcomes (lung function, symptoms, quality of life, history of exacerbations, BODCAT and BODEx). In addition, only UCR differentiated patients with different severity of airflow limitation as well as symptoms and exacerbations. The great individual predictive potential of UCR and IL-1β was observed with their odds ratios (OR) being 2.09 and 5.53, respectively. Multiparameter models of UA and UCR that included IL-1β were able to correctly classify 86% and 90% of cases, respectively. Conclusions: We suggest that UA might be a useful biomarker when combined with IL-1β, while UCR might be even more informative and useful in overall COPD assessments.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
IP-2014-09-1247 - Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti (Hsp70COPD) (HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za plućne bolesti "Jordanovac",
Klinički bolnički centar Zagreb

Profili:

Avatar Url Iva Hlapčić (autor)

Avatar Url Ivana Rako (autor)

Avatar Url Ivana Čepelak (autor)

Avatar Url Dunja Rogić (autor)

Avatar Url Lada Rumora (autor)

Avatar Url Sanja Popović-Grle (autor)

Citiraj ovu publikaciju

Rumora, Lada; Hlapčić, Iva; Popović-Grle, Sanja; Rako, Ivana; Rogić, Dunja; Čepelak, Ivana
Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: potential biomarkers in multicomponent models comprising IL-1beta // PLoS One, 15 (2020), 6; e0234363-e0234363 doi:10.1371/journal.pone.0234363 (međunarodna recenzija, članak, znanstveni)
Rumora, L., Hlapčić, I., Popović-Grle, S., Rako, I., Rogić, D. & Čepelak, I. (2020) Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: potential biomarkers in multicomponent models comprising IL-1beta. PLoS One, 15 (6), e0234363-e0234363 doi:10.1371/journal.pone.0234363.
@article{article, year = {2020}, pages = {e0234363-e0234363}, DOI = {10.1371/journal.pone.0234363}, keywords = {chronic obstructive pulmonary disease, uric acid, uric acid to creatinine ratio, interleukin 1beta, inflammasome}, journal = {PLoS One}, doi = {10.1371/journal.pone.0234363}, volume = {15}, number = {6}, issn = {1932-6203}, title = {Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: potential biomarkers in multicomponent models comprising IL-1beta}, keyword = {chronic obstructive pulmonary disease, uric acid, uric acid to creatinine ratio, interleukin 1beta, inflammasome} }
@article{article, year = {2020}, pages = {e0234363-e0234363}, DOI = {10.1371/journal.pone.0234363}, keywords = {chronic obstructive pulmonary disease, uric acid, uric acid to creatinine ratio, interleukin 1beta, inflammasome}, journal = {PLoS One}, doi = {10.1371/journal.pone.0234363}, volume = {15}, number = {6}, issn = {1932-6203}, title = {Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: potential biomarkers in multicomponent models comprising IL-1beta}, keyword = {chronic obstructive pulmonary disease, uric acid, uric acid to creatinine ratio, interleukin 1beta, inflammasome} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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