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The role of CCL2, CXCL8 and IL-10 in pathogenesis of hemorrhagic fever with renal syndrome and leptospirosis

Hemorrhagic fever with renal syndrome (HFRS) and leptospirosis are acute febrile diseases most commonly affecting the kidneys. Pulmonary and liver disorders are also common. The clinical picture of HFRS can closely mimic that of unicteric leptospirosis, and vice versa. Dual infections are possible. Little is known about the pathogenesis of HFRS and even less about leptospirosis. The aim of our study was to compare the role CCL2 (MCP-1), CXCL8 (interleukine (IL)-8) and IL-10 in patients with HFRS, leptospirosis or dual infections. The levels of IL-10, CCL2 and CXCL8 were measured in patient's sera by commercial ELISA sets. HFRS and leptospirosis were serologically confirmed by ELISA IgM and IgG tests. The level of CCL2 and CXCL8 were significantly higher in patients with HFRS or leptospirosis than in negative controls, but there were no significant differences in the levels of both chemokines between patients with HFRS or leptospirosis. IL-10 was elevated in about 30% of patients in the early acute phase of both diseases. The level of IL-10 in patients with leptospirosis was higher than in patients with HFRS and correlated with the level of creatinine and total bilirubin. Two patients with dual infection with leptospira and virus Dobrava suggest that patients with dual infection may have stronger immune response than patients with HFRS or leptospirosis only.

CCL2; CXCL8; IL. HFRS

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