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Pregled bibliografske jedinice broj: 1088954

Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential


Cvetko, Ana; Kifer, Domagoj; Gornik, Olga; Klarić, Lucija; Visser, Elizabeth; Lauc, Gordan; Wilson, James F.; Štambuk, Tamara
Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential // Biomedicines, 8 (2020), 10; 410, 14 doi:10.3390/biomedicines8100410 (međunarodna recenzija, članak, znanstveni)


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Naslov
Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential

Autori
Cvetko, Ana ; Kifer, Domagoj ; Gornik, Olga ; Klarić, Lucija ; Visser, Elizabeth ; Lauc, Gordan ; Wilson, James F. ; Štambuk, Tamara

Izvornik
Biomedicines (2227-9059) 8 (2020), 10; 410, 14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
immunoglobulin G in inflammation ; multiple sclerosis ; N-glycosylation ; plasma glycoproteins ; biomarkers

Sažetak
Multiple sclerosis (MS) is an inflammatory autoimmune disorder affecting the central nervous system (CNS), with unresolved aetiology. Previous studies have implicated N- glycosylation, a highly regulated enzymatic attachment of complex sugars to targeted proteins, in MS pathogenesis. We investigated individual variation in N-glycosylation of the total plasma proteome and of IgG in MS. Both plasma protein and IgG N-glycans were chromatographically profiled and quantified in 83 MS cases and 88 age- and sex-matched controls. Comparing levels of glycosylation features between MS cases and controls revealed that core fucosylation (p = 6.96 × 10−3) and abundance of high-mannose structures (p = 1.48 × 10−2) were the most prominently altered IgG glycosylation traits. Significant changes in plasma protein N-glycome composition were observed for antennary fucosylated, tri- and tetrasialylated, tri- and tetragalactosylated, high-branched N-glycans (p-value range 1.66 × 10−2–4.28 × 10−2). Classification performance of N-glycans was examined by ROC curve analysis, resulting in an AUC of 0.852 for the total plasma N-glycome and 0.798 for IgG N- glycome prediction models. Our results indicate that multiple aspects of protein glycosylation are altered in MS, showing increased proinflammatory potential. N-glycan alterations showed substantial value in classification of the disease status, nonetheless, additional studies are warranted to explore their exact role in MS development and utility as biomarkers.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Tamara Štambuk (autor)

Avatar Url Olga Gornik Kljaić (autor)

Avatar Url Domagoj Kifer (autor)

Avatar Url Ana Cvetko (autor)

Avatar Url Gordan Lauc (autor)

Citiraj ovu publikaciju

Cvetko, Ana; Kifer, Domagoj; Gornik, Olga; Klarić, Lucija; Visser, Elizabeth; Lauc, Gordan; Wilson, James F.; Štambuk, Tamara
Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential // Biomedicines, 8 (2020), 10; 410, 14 doi:10.3390/biomedicines8100410 (međunarodna recenzija, članak, znanstveni)
Cvetko, A., Kifer, D., Gornik, O., Klarić, L., Visser, E., Lauc, G., Wilson, J. & Štambuk, T. (2020) Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential. Biomedicines, 8 (10), 410, 14 doi:10.3390/biomedicines8100410.
@article{article, year = {2020}, pages = {14}, DOI = {10.3390/biomedicines8100410}, chapter = {410}, keywords = {immunoglobulin G in inflammation, multiple sclerosis, N-glycosylation, plasma glycoproteins, biomarkers}, journal = {Biomedicines}, doi = {10.3390/biomedicines8100410}, volume = {8}, number = {10}, issn = {2227-9059}, title = {Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential}, keyword = {immunoglobulin G in inflammation, multiple sclerosis, N-glycosylation, plasma glycoproteins, biomarkers}, chapternumber = {410} }
@article{article, year = {2020}, pages = {14}, DOI = {10.3390/biomedicines8100410}, chapter = {410}, keywords = {immunoglobulin G in inflammation, multiple sclerosis, N-glycosylation, plasma glycoproteins, biomarkers}, journal = {Biomedicines}, doi = {10.3390/biomedicines8100410}, volume = {8}, number = {10}, issn = {2227-9059}, title = {Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential}, keyword = {immunoglobulin G in inflammation, multiple sclerosis, N-glycosylation, plasma glycoproteins, biomarkers}, chapternumber = {410} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus


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