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Pregled bibliografske jedinice broj: 1088623

Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer – single institution experience


Ban, Marija; Viculin, Jelena; Tomić, Snježana; Čapkun, Vesna; Strikić, Ante; Petrić Miše, Branka; Utrobičić, Ivan; Vrdoljak, Eduard
Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer – single institution experience // Neoplasma, 63 (2016), 5; 761-767 doi:10.4149/neo_2016_513 (međunarodna recenzija, članak, stručni)


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Naslov
Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer – single institution experience

Autori
Ban, Marija ; Viculin, Jelena ; Tomić, Snježana ; Čapkun, Vesna ; Strikić, Ante ; Petrić Miše, Branka ; Utrobičić, Ivan ; Vrdoljak, Eduard

Izvornik
Neoplasma (0028-2685) 63 (2016), 5; 761-767

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
trastuzumab ; adjuvant chemotherapy in HER2 ; early breast cancer ; retrospective analysis

Sažetak
Addition of trastuzumab to chemotherapy is the cornerstone of adjuvant treatment of early HER2 positive breast cancer. Clinical trials and metaanalyses of adjuvant trastuzumab have shown significant reduction in risk of recurrence and death. Nevertheless, the real magnitude of the effect of any drug must be reevaluated in daily clinical conditions, due to the fact that daily clinical practice often differs from conditions in clinical trials. In order to measure the benefit of adding adjuvant trastuzumab in HER 2 positive early breast cancer treatment, we have performed retrospective analysis in a single institution on consecutive patients divided in 2 cohorts: one, treated in “pre – trastuzumab” and the other in “trastuzumab era”. Between 2003 and 2012, 258 consecutive HER 2 positive patients with early breast cancer have been treated with adjuvant chemotherapy, 103 patients did not received trastuzumab (patients treated from 2003 till 2007), and 155 (patients treated from 2008 till 2012) received trastuzumab. Patients who received trastuzumab experienced significantly longer median disease-free survival (107 vs. 92 months, LR: 11.6, p <0.001) ; breast cancer-specific survival (130 vs. 117 months, LR: 10.7, p < 0.001) and median overall survival (123 vs. 108 months LR = 11.6, p < 0.001). The benefits of adding trastuzumab were independent of chemotherapy regimen and hormonal therapy. This retrospective analysis has shown a clear, statistically significant benefit of adjuvant trastuzumab in treatment of early, HER2 positive breast cancer in daily clinical practice, and confirmed the results of the registration clinical trials.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC Split

Citiraj ovu publikaciju

Ban, Marija; Viculin, Jelena; Tomić, Snježana; Čapkun, Vesna; Strikić, Ante; Petrić Miše, Branka; Utrobičić, Ivan; Vrdoljak, Eduard
Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer – single institution experience // Neoplasma, 63 (2016), 5; 761-767 doi:10.4149/neo_2016_513 (međunarodna recenzija, članak, stručni)
Ban, M., Viculin, J., Tomić, S., Čapkun, V., Strikić, A., Petrić Miše, B., Utrobičić, I. & Vrdoljak, E. (2016) Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer – single institution experience. Neoplasma, 63 (5), 761-767 doi:10.4149/neo_2016_513.
@article{article, year = {2016}, pages = {761-767}, DOI = {10.4149/neo\_2016\_513}, keywords = {trastuzumab, adjuvant chemotherapy in HER2, early breast cancer, retrospective analysis}, journal = {Neoplasma}, doi = {10.4149/neo\_2016\_513}, volume = {63}, number = {5}, issn = {0028-2685}, title = {Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer – single institution experience}, keyword = {trastuzumab, adjuvant chemotherapy in HER2, early breast cancer, retrospective analysis} }
@article{article, year = {2016}, pages = {761-767}, DOI = {10.4149/neo\_2016\_513}, keywords = {trastuzumab, adjuvant chemotherapy in HER2, early breast cancer, retrospective analysis}, journal = {Neoplasma}, doi = {10.4149/neo\_2016\_513}, volume = {63}, number = {5}, issn = {0028-2685}, title = {Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer – single institution experience}, keyword = {trastuzumab, adjuvant chemotherapy in HER2, early breast cancer, retrospective analysis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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