Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1088086

New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions


Bennett Saidu, Nathaniel Edward; Bonini, Chiara; Dickinson, Anne; Grce, Magdalena; Inngjerdingen, Marit; Koehl, Ulrike; Toubert, Antoine; Zeiser, Robert; Galimberti, Sara
New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions // Frontiers in Immunology, 11 (2020), 578314, 19 doi:10.3389/fimmu.2020.578314 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1088086 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions

Autori
Bennett Saidu, Nathaniel Edward ; Bonini, Chiara ; Dickinson, Anne ; Grce, Magdalena ; Inngjerdingen, Marit ; Koehl, Ulrike ; Toubert, Antoine ; Zeiser, Robert ; Galimberti, Sara

Izvornik
Frontiers in Immunology (1664-3224) 11 (2020); 578314, 19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
chronic graft-versus-host disease, tyrosine kinase inhibitors, immunotherapy, Janus kinase 1/2, hematopoietic stem cell transplantation

Sažetak
Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation that affects various organs leading to a reduced quality of life. The condition often requires enduring immunosuppressive therapy, which can also lead to the development of severe side effects. Several approaches including small molecule inhibitors, antibodies, cytokines, and cellular therapies are now being developed for the treatment of cGvHD, and some of these therapies have been or are currently tested in clinical trials. In this review, we discuss these emerging therapies with particular emphasis on tyrosine kinase inhibitors (TKIs). TKIs are a class of compounds that inhibits tyrosine kinases, thereby preventing the dissemination of growth signals and activation of key cellular proteins that are involved in cell growth and division. Because they have been shown to inhibit key kinases in both B cells and T cells that are involved in the pathophysiology of cGvHD, TKIs present new promising therapeutic approaches. Ibrutinib, a Bruton tyrosine kinase (Btk) inhibitor, has recently been approved by the Food and Drug Administration (FDA) in the United States for the treatment of adult patients with cGvHD after failure of first-line of systemic therapy. Also, Janus Associated Kinases (JAK1 and JAK2) inhibitors, such as itacitinib (JAK1) and ruxolitinib (JAK1 and 2), are promising in the treatment of cGvHD. Herein, we present the current status and future directions of the use of these new drugs with particular spotlight on their targeting of specific intracellular signal transduction cascades important for cGvHD, in order to shed some light on their possible mode of actions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
COST-CA17138 - Integrated European Network on Chronic Graft Versus Host Disease (cGvHD) (EUROGRAFT) (Grce, Magdalena, COST ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Bennett Saidu, Nathaniel Edward; Bonini, Chiara; Dickinson, Anne; Grce, Magdalena; Inngjerdingen, Marit; Koehl, Ulrike; Toubert, Antoine; Zeiser, Robert; Galimberti, Sara
New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions // Frontiers in Immunology, 11 (2020), 578314, 19 doi:10.3389/fimmu.2020.578314 (međunarodna recenzija, pregledni rad, znanstveni)
Bennett Saidu, N., Bonini, C., Dickinson, A., Grce, M., Inngjerdingen, M., Koehl, U., Toubert, A., Zeiser, R. & Galimberti, S. (2020) New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions. Frontiers in Immunology, 11, 578314, 19 doi:10.3389/fimmu.2020.578314.
@article{article, year = {2020}, pages = {19}, DOI = {10.3389/fimmu.2020.578314}, chapter = {578314}, keywords = {chronic graft-versus-host disease, tyrosine kinase inhibitors, immunotherapy, Janus kinase 1/2, hematopoietic stem cell transplantation}, journal = {Frontiers in Immunology}, doi = {10.3389/fimmu.2020.578314}, volume = {11}, issn = {1664-3224}, title = {New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions}, keyword = {chronic graft-versus-host disease, tyrosine kinase inhibitors, immunotherapy, Janus kinase 1/2, hematopoietic stem cell transplantation}, chapternumber = {578314} }
@article{article, year = {2020}, pages = {19}, DOI = {10.3389/fimmu.2020.578314}, chapter = {578314}, keywords = {chronic graft-versus-host disease, tyrosine kinase inhibitors, immunotherapy, Janus kinase 1/2, hematopoietic stem cell transplantation}, journal = {Frontiers in Immunology}, doi = {10.3389/fimmu.2020.578314}, volume = {11}, issn = {1664-3224}, title = {New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions}, keyword = {chronic graft-versus-host disease, tyrosine kinase inhibitors, immunotherapy, Janus kinase 1/2, hematopoietic stem cell transplantation}, chapternumber = {578314} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font