engleski

Twisted bacteria in Nature, Medicine and Biotechnology

Streptomyces species have a very complex lifestyle and are one of the best known mycelial genera of Actinobacteria. These bacteria produce an impressive number of diverse bioactive secondary metabolites, among which are antibiotics in current clinical use, as well as many anticancer, antifungal or immunosuppressive compounds. Streptomycetes also exhibit genetic adaptability to a wide range of terrestrial and aquatic environments. In their natural habitats these bacteria have a major role in degrading organic matter. They use their genome potential to produce a wide range of extracellular hydrolytic enzymes. Consequently, these bacteria are of great interest in medicine and industry. The emergence of multi-resistant microorganisms to almost all available antibiotics focused research efforts to re- evaluate these organisms. Streptomyces genomic studies confirmed them as a source of vital new antibiotics and this led to an increase of screening programmes to uncover novel species in diverse ecological niches. In this talk, a few special features of Streptomyces biology will be emphasized: the complex life cycle and how essential proteins of DNA metabolism can be manipulated to increase antibiotic production and their potential for synthesis of a broad spectrum of multifunctional lipolytic enzymes. In addition, the capacity of Actinobacteria to inhabit contaminated ecological niches in selected ecosystems of Northern Adriatic sea will be discussed.

Streptomyces, diverse bioactive secondary metabolites, Actinobacteria in selected ecosystems of Northern Adriatic se

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