Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1087722

The TRIOBP Isoforms and Their Distinct Roles in Actin Stabilization, Deafness, Mental Illness, and Cancer


Zaharija, Beti; Samardžija, Bobana; Bradshaw, Nicholas J.
The TRIOBP Isoforms and Their Distinct Roles in Actin Stabilization, Deafness, Mental Illness, and Cancer // Molecules, 25 (2020), 21; 4967, 18 doi:10.3390/molecules25214967 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1087722 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The TRIOBP Isoforms and Their Distinct Roles in Actin Stabilization, Deafness, Mental Illness, and Cancer

Autori
Zaharija, Beti ; Samardžija, Bobana ; Bradshaw, Nicholas J.

Izvornik
Molecules (1420-3049) 25 (2020), 21; 4967, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
TRIOBP ; Cancer ; Deafness ; Hearing loss ; Mental illness ; Schizophrenia ; Actin ; Cytoskeleton ; Disordered structure ; Protein aggregation

Sažetak
The TRIOBP (TRIO and F-actin Binding Protein) gene encodes multiple proteins, which together play crucial roles in modulating the assembly of the actin cytoskeleton. Splicing of the TRIOBP gene is complex, with the two most studied TRIOBP protein isoforms sharing no overlapping amino acid sequence with each other. TRIOBP-1 (also known as TARA or TAP68) is a mainly structured protein that is ubiquitously expressed and binds to F-actin, preventing its depolymerization. It has been shown to be important for many processes including in the cell cycle, adhesion junctions, and neuronal differentiation. TRIOBP-1 has been implicated in schizophrenia through the formation of protein aggregates in the brain. In contrast, TRIOBP-4 is an entirely disordered protein with a highly specialized expression pattern. It is known to be crucial for the bundling of actin in the stereocilia of the inner ear, with mutations in it causing severe or profound hearing loss. Both of these isoforms are implicated in cancer. Additional longer isoforms of TRIOBP exist, which overlap with both TRIOBP-1 and 4. These appear to participate in the functions of both shorter isoforms, while also possessing unique functions in the inner ear. In this review, the structures and functions of all of these isoforms are discussed, with a view to understanding how they operate, both alone and in combination, to modulate actin and their consequences for human illness

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-9424 - Istraživanje shizofrenije kroz ekspresiju netopivih proteina (CandidIskren) (Bradshaw, Nicholas James, HRZZ - 2018-01) ( POIROT)
HRZZ-DOK-2020-01-8580 - Istraživanje shizofrenije kroz ekspresiju netopivih proteina (CandidIskren) (Bradshaw, Nicholas James, HRZZ - DOK-2020-01) ( POIROT)
HRZZ-DOK-2018-09-5395 - Istraživanje shizofrenije kroz ekspresiju netopivih proteina (CandidIskren) (Bradshaw, Nicholas James, HRZZ - DOK-2018-09) ( POIROT)

Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.mdpi.com

Citiraj ovu publikaciju:

Zaharija, Beti; Samardžija, Bobana; Bradshaw, Nicholas J.
The TRIOBP Isoforms and Their Distinct Roles in Actin Stabilization, Deafness, Mental Illness, and Cancer // Molecules, 25 (2020), 21; 4967, 18 doi:10.3390/molecules25214967 (međunarodna recenzija, pregledni rad, znanstveni)
Zaharija, B., Samardžija, B. & Bradshaw, N. (2020) The TRIOBP Isoforms and Their Distinct Roles in Actin Stabilization, Deafness, Mental Illness, and Cancer. Molecules, 25 (21), 4967, 18 doi:10.3390/molecules25214967.
@article{article, author = {Zaharija, Beti and Samard\v{z}ija, Bobana and Bradshaw, Nicholas J.}, year = {2020}, pages = {18}, DOI = {10.3390/molecules25214967}, chapter = {4967}, keywords = {TRIOBP, Cancer, Deafness, Hearing loss, Mental illness, Schizophrenia, Actin, Cytoskeleton, Disordered structure, Protein aggregation}, journal = {Molecules}, doi = {10.3390/molecules25214967}, volume = {25}, number = {21}, issn = {1420-3049}, title = {The TRIOBP Isoforms and Their Distinct Roles in Actin Stabilization, Deafness, Mental Illness, and Cancer}, keyword = {TRIOBP, Cancer, Deafness, Hearing loss, Mental illness, Schizophrenia, Actin, Cytoskeleton, Disordered structure, Protein aggregation}, chapternumber = {4967} }
@article{article, author = {Zaharija, Beti and Samard\v{z}ija, Bobana and Bradshaw, Nicholas J.}, year = {2020}, pages = {18}, DOI = {10.3390/molecules25214967}, chapter = {4967}, keywords = {TRIOBP, Cancer, Deafness, Hearing loss, Mental illness, Schizophrenia, Actin, Cytoskeleton, Disordered structure, Protein aggregation}, journal = {Molecules}, doi = {10.3390/molecules25214967}, volume = {25}, number = {21}, issn = {1420-3049}, title = {The TRIOBP Isoforms and Their Distinct Roles in Actin Stabilization, Deafness, Mental Illness, and Cancer}, keyword = {TRIOBP, Cancer, Deafness, Hearing loss, Mental illness, Schizophrenia, Actin, Cytoskeleton, Disordered structure, Protein aggregation}, chapternumber = {4967} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font