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Pregled bibliografske jedinice broj: 1087305

Bio-Naive Crohn's Disease Patients with Long- Standing Disease Benefit from Ustekinumab Treatment: Real World Experience


(Univerzitetni klinični center Ljubljana) Tomasic, Vedran; Drobne, David; Borzan, Vladimir; Bišćanin, Alen; Hanžel, Jurij; Oršić Frič, Vlasta; Ćaćić, Petra, Štabuc, Borut; Ogresta, Doris; Kralj, Dominik; Dorosulić, Zdravko; Hrabar, Davor
Bio-Naive Crohn's Disease Patients with Long- Standing Disease Benefit from Ustekinumab Treatment: Real World Experience // UEG Week 2020 Poster Presentations
virtualni kongres: SAGE Publications, 2020. str. 330-330 doi:10.1177/2050640620927345 (poster, međunarodna recenzija, sažetak, ostalo)


CROSBI ID: 1087305 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bio-Naive Crohn's Disease Patients with Long- Standing Disease Benefit from Ustekinumab Treatment: Real World Experience

Autori
Tomasic, Vedran ; Drobne, David ; Borzan, Vladimir ; Bišćanin, Alen ; Hanžel, Jurij ; Oršić Frič, Vlasta ; Ćaćić, Petra, Štabuc, Borut ; Ogresta, Doris ; Kralj, Dominik ; Dorosulić, Zdravko ; Hrabar, Davor

Kolaboracija
Univerzitetni klinični center Ljubljana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
UEG Week 2020 Poster Presentations / - : SAGE Publications, 2020, 330-330

Skup
UEG Week Virtual 2020

Mjesto i datum
Virtualni kongres, 11-13. 10. 2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ustekinumab, Crohn disease

Sažetak
Introduction: Ustekinumab (UST) is a human anti- IL12/23 p40 monoclonal antibody, approved for treatment of Crohn’s Disease (CD). This multicenter, non-interventional, retrospective chart review explored robust real-life data in patients receiving UST to access long-term efficacy and treatment persistence of UST treatment in the bio- naive CD population with long-standing disease. Aims & Methods: Clinical data, such as maintenance of clinical response using Harvey-Bradshaw index, combined steroid-free and biochemical clinical remission, endoscopic response/healing via the simple endoscopic score for Crohn’s disease (SES-CD), dose escalation and treatment persistence were assessed in 42 adult patients (55% female ; mean age 46 ± 15.1 years ; mean BMI 25.28 ± 4.5 kg/m2 ) with long-standing (mean duration of 10, 5 years) biologic-naive CD from 3 tertiary centers (one Slovenian and two Croatian) between January 2018 and April 2020. Data were collected before first infusion, at week (W)24, W52, as well as last follow-up. Results: At W24 84% (35/42) of CD patients had achieved clinical response and 38.1% (16/42) were in combined steroid-free and biochemical clinical remission. After an average of 16 months of treatment duration, 88.1% (37/42) of CD patients were still on UST treatment, 71.4% (30/42) had maintained clinical response and 35.7% (15/42) were in sustained steroidfree clinical remission. The number of patients requiring steroid treatment was reduced by 87%. Mean HBI decreased from 8 to 3 and SES-CD from 6 to 2. The majority [59.53%] of patients started ustekinumab as monotherapy, i.e. without concomitant immunomodulator medication. 31% of patients experienced UST dose escalation. Conclusion: UST offers an effective and persistent steroid sparing treatment option in this real-life multicenter study of bio-naive CD patients with long-standing disease.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Davor Hrabar (autor)

Avatar Url Petra Ćaćić (autor)

Avatar Url Vedran Tomašić (autor)

Avatar Url Alen Bišćanin (autor)

Citiraj ovu publikaciju

(Univerzitetni klinični center Ljubljana) Tomasic, Vedran; Drobne, David; Borzan, Vladimir; Bišćanin, Alen; Hanžel, Jurij; Oršić Frič, Vlasta; Ćaćić, Petra, Štabuc, Borut; Ogresta, Doris; Kralj, Dominik; Dorosulić, Zdravko; Hrabar, Davor
Bio-Naive Crohn's Disease Patients with Long- Standing Disease Benefit from Ustekinumab Treatment: Real World Experience // UEG Week 2020 Poster Presentations
virtualni kongres: SAGE Publications, 2020. str. 330-330 doi:10.1177/2050640620927345 (poster, međunarodna recenzija, sažetak, ostalo)
(Univerzitetni klinični center Ljubljana) (Univerzitetni klinični center Ljubljana) Tomasic, V., Drobne, D., Borzan, V., Bišćanin, A., Hanžel, J., Oršić Frič, V., Ćaćić, Petra, Štabuc, Borut, Ogresta, D., Kralj, D., Dorosulić, Z. & Hrabar, D. (2020) Bio-Naive Crohn's Disease Patients with Long- Standing Disease Benefit from Ustekinumab Treatment: Real World Experience. U: UEG Week 2020 Poster Presentations doi:10.1177/2050640620927345.
@article{article, year = {2020}, pages = {330-330}, DOI = {10.1177/2050640620927345}, keywords = {ustekinumab, Crohn disease}, doi = {10.1177/2050640620927345}, title = {Bio-Naive Crohn's Disease Patients with Long- Standing Disease Benefit from Ustekinumab Treatment: Real World Experience}, keyword = {ustekinumab, Crohn disease}, publisher = {SAGE Publications}, publisherplace = {virtualni kongres} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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