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Pregled bibliografske jedinice broj: 1087162

Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics


Jednačak, Tomislav; Mikulandra, Ivana; Novak, Predrag
Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics // International journal of molecular sciences, 21 (2020), 20; 7799, 26 doi:10.3390/ijms21207799 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics

Autori
Jednačak, Tomislav ; Mikulandra, Ivana ; Novak, Predrag

Izvornik
International journal of molecular sciences (1422-0067) 21 (2020), 20; 7799, 26

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
structure characterization ; macrolide antibiotics ; macrolide interactions ; biomolecular targets ; X-ray crystallography ; cryo-electron microscopy ; NMR spectroscopy ; biochemical and fluorescence methods ; molecular dynamics simulations

Sažetak
Macrolide antibiotics are macrocyclic compounds that are clinically used and prescribed for the treatment of upper and lower respiratory tract infections. They inhibit the synthesis of bacterial proteins by reversible binding to the 23S rRNA at or near the peptidyl transferase center. However, their excellent antibacterial profile was largely compromised by the emergence of bacterial resistance. Today, fighting resistance to antibiotics is one of the greatest challenges in medicinal chemistry. Considering various physicochemical properties of macrolides, understanding their structure and interactions with macromolecular targets is crucial for the design of new antibiotics efficient against resistant pathogens. The solid state structures of some macrolide- ribosome complexes have recently been solved, throwing new light on the macrolide binding mechanisms. On the other hand, a combination of NMR spectroscopy and molecular modeling calculations can be applied to study free and bound conformations in solution. In this article, a description of advanced physicochemical methods for elucidating the structure and interactions of macrolide antibiotics in solid state and solution will be provided, and their principal advantages and drawbacks will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-8098 - Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije (Makrozoni/Macrozones) (Novak, Predrag, HRZZ - 2018-01) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Tomislav Jednačak (autor)

Avatar Url Ivana Mikulandra (autor)

Avatar Url Predrag Novak (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com www.mdpi.com

Citiraj ovu publikaciju:

Jednačak, Tomislav; Mikulandra, Ivana; Novak, Predrag
Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics // International journal of molecular sciences, 21 (2020), 20; 7799, 26 doi:10.3390/ijms21207799 (međunarodna recenzija, pregledni rad, znanstveni)
Jednačak, T., Mikulandra, I. & Novak, P. (2020) Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics. International journal of molecular sciences, 21 (20), 7799, 26 doi:10.3390/ijms21207799.
@article{article, year = {2020}, pages = {26}, DOI = {10.3390/ijms21207799}, chapter = {7799}, keywords = {structure characterization, macrolide antibiotics, macrolide interactions, biomolecular targets, X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, biochemical and fluorescence methods, molecular dynamics simulations}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms21207799}, volume = {21}, number = {20}, issn = {1422-0067}, title = {Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics}, keyword = {structure characterization, macrolide antibiotics, macrolide interactions, biomolecular targets, X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, biochemical and fluorescence methods, molecular dynamics simulations}, chapternumber = {7799} }
@article{article, year = {2020}, pages = {26}, DOI = {10.3390/ijms21207799}, chapter = {7799}, keywords = {structure characterization, macrolide antibiotics, macrolide interactions, biomolecular targets, X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, biochemical and fluorescence methods, molecular dynamics simulations}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms21207799}, volume = {21}, number = {20}, issn = {1422-0067}, title = {Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics}, keyword = {structure characterization, macrolide antibiotics, macrolide interactions, biomolecular targets, X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, biochemical and fluorescence methods, molecular dynamics simulations}, chapternumber = {7799} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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