Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1086525

Solvent dependent 4-aminosalicylic acid- sulfamethazine co-crystal polymorph control


Salem, Ala’; Hagymási, Alexandra; Vörös- Horváth, Barbara; Šafarik, Tatjana; Balić, Tomislav; Szabó, Péter; Gősi, Fruzsina; Nagy, Sándor; Pál, Szilárd; Kunsági-Máté, Sándor; Széchenyi, Aleksandar
Solvent dependent 4-aminosalicylic acid- sulfamethazine co-crystal polymorph control // European journal of pharmaceutical sciences, 156 (2021), 105599, 7 doi:10.1016/j.ejps.2020.105599 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1086525 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Solvent dependent 4-aminosalicylic acid- sulfamethazine co-crystal polymorph control

Autori
Salem, Ala’ ; Hagymási, Alexandra ; Vörös- Horváth, Barbara ; Šafarik, Tatjana ; Balić, Tomislav ; Szabó, Péter ; Gősi, Fruzsina ; Nagy, Sándor ; Pál, Szilárd ; Kunsági-Máté, Sándor ; Széchenyi, Aleksandar

Izvornik
European journal of pharmaceutical sciences (0928-0987) 156 (2021); 105599, 7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Co-crystal ; Polymorph ; Multi-drug ; Hansen solubility parameters ; 4-aminosalicylic acid ; Sulfamethazine

Sažetak
Despite polymorphism of crystalline active pharmaceutical ingredients (APIs) being a common phenomenon, reports on polymorphic co- crystals are limited. As polymorphism can vastly affect API properties, controlling polymorph generation is crucial. Control of the polymorph nucleation through the use of different solvents during solution crystallization has been used to obtain a desirable crystal polymorph. There have been two reported polymorphic forms of the 4- aminosalicylic acid-sulfamethazine co-crystals. These forms were found to have different thermodynamic stabilities. However, the control of co-crystal polymorph generation using preparation parameter manipulation has never been reported. The aim of this study was to establish the effect of different solvent parameters on the formation of different co- crystal polymorphic forms. Selection of the solvents was based on Hansen Solubility Parameters (HSPs) as solvents with different solubility parameters are likely to interact differently with APIs, ultimately affecting co- crystallization. Eight solvents with different HSPs were used to prepare co-crystals by solvent evaporation at two different temperatures. Through characterization of the co-crystals, a new polymorph has been obtained. The hydrogen bond acceptability seemed to affect the co-crystal form obtained more than the hydrogen bond donation ability. Furthermore, the use of HSPs can be utilized as an easy calculation method in screening and design of co-crystals.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Ustanove:
Sveučilište u Osijeku - Odjel za kemiju

Citiraj ovu publikaciju

Salem, Ala’; Hagymási, Alexandra; Vörös- Horváth, Barbara; Šafarik, Tatjana; Balić, Tomislav; Szabó, Péter; Gősi, Fruzsina; Nagy, Sándor; Pál, Szilárd; Kunsági-Máté, Sándor; Széchenyi, Aleksandar
Solvent dependent 4-aminosalicylic acid- sulfamethazine co-crystal polymorph control // European journal of pharmaceutical sciences, 156 (2021), 105599, 7 doi:10.1016/j.ejps.2020.105599 (međunarodna recenzija, članak, znanstveni)
Salem, A., Hagymási, A., Vörös- Horváth, B., Šafarik, T., Balić, T., Szabó, P., Gősi, F., Nagy, S., Pál, S., Kunsági-Máté, S. & Széchenyi, A. (2021) Solvent dependent 4-aminosalicylic acid- sulfamethazine co-crystal polymorph control. European journal of pharmaceutical sciences, 156, 105599, 7 doi:10.1016/j.ejps.2020.105599.
@article{article, year = {2021}, pages = {7}, DOI = {10.1016/j.ejps.2020.105599}, chapter = {105599}, keywords = {Co-crystal, Polymorph, Multi-drug, Hansen solubility parameters, 4-aminosalicylic acid, Sulfamethazine}, journal = {European journal of pharmaceutical sciences}, doi = {10.1016/j.ejps.2020.105599}, volume = {156}, issn = {0928-0987}, title = {Solvent dependent 4-aminosalicylic acid- sulfamethazine co-crystal polymorph control}, keyword = {Co-crystal, Polymorph, Multi-drug, Hansen solubility parameters, 4-aminosalicylic acid, Sulfamethazine}, chapternumber = {105599} }
@article{article, year = {2021}, pages = {7}, DOI = {10.1016/j.ejps.2020.105599}, chapter = {105599}, keywords = {Co-crystal, Polymorph, Multi-drug, Hansen solubility parameters, 4-aminosalicylic acid, Sulfamethazine}, journal = {European journal of pharmaceutical sciences}, doi = {10.1016/j.ejps.2020.105599}, volume = {156}, issn = {0928-0987}, title = {Solvent dependent 4-aminosalicylic acid- sulfamethazine co-crystal polymorph control}, keyword = {Co-crystal, Polymorph, Multi-drug, Hansen solubility parameters, 4-aminosalicylic acid, Sulfamethazine}, chapternumber = {105599} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font