engleski

Neurotoxic effects of selected pesticides by altering cholinesterase activity

Due to their role in the protection of herbs, pesticides are globally widespread and can have a deleterious effect on human health. The neurological system is particularly susceptible to adverse effects from pesticide exposure. Selected pesticides such as metamiphos, phenamidophos, ethoprophos, phosalone, and acetamiprid are neuroactive insecticides with neurotransmitter cascades as their main targets. Inhibition of acetylcholinesterase (AChE) by organophosphate (OP) compounds is a well-known mechanism of intoxication. The disruption of nicotine acetylcholine receptors (nAChRs) through agonists such as acetamiprid can lead to toxic effects by inhibiting AChE in the synaptic cleft. To gain better insight for the purposes of intoxication monitoring, alterations in cholinesterase activity were observed together with interactions of pesticides with active site residues of cholinesterases, revealing the possible orientation of the inhibitors. The focus of this study was to achieve a better comprehension of the action mechanisms and effects that selected pesticides have on cholinergic neurotransmission and afterwards attain the best intervention solution for pesticide intoxication. Keywords: organophosphate

Organophosphate pesticides, cholinesterase, cholinergic neurotransmission.

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