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Pregled bibliografske jedinice broj: 1085466

Incidence and risk factors for gangrene in patients with systemic sclerosis from the EUSTAR cohort


(EUSTAR) Mihai, Carina; Distler, Oliver; Gheorghiu, Ana Maria; Constantin, Paul I; Dobrota, Rucsandra; Jordan, Suzana; Smith, Vanessa; Hachulla, Eric; Henes, Jörg; Siegert, Elise et al.
Incidence and risk factors for gangrene in patients with systemic sclerosis from the EUSTAR cohort // Rheumatology, 59 (2020), 8; 2016-2023 doi:10.1093/rheumatology/kez558 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1085466 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Incidence and risk factors for gangrene in patients with systemic sclerosis from the EUSTAR cohort

Autori
Mihai, Carina ; Distler, Oliver ; Gheorghiu, Ana Maria ; Constantin, Paul I ; Dobrota, Rucsandra ; Jordan, Suzana ; Smith, Vanessa ; Hachulla, Eric ; Henes, Jörg ; Siegert, Elise ; Vettori, Serena ; Müller-Ladner, Ulf ; Matucci Cerinic, Marco ; Allanore, Yannick ; Lepri, Gemma ; Jaeger, Veronika K ; Walker, Ulrich A ; Iannone, Florenzo ; Cacciapaglia, Fabio ; Tomčík, Michal ; Becvar, Radim ; Rednic, Simona ; Petcu, Ana ; Szabo, Iulia ; Codullo, Veronica ; Caporali, Roberto ; Montecucco, Carlomaurizio ; Carreira, Patricia ; Ioven, Beatriz ; Minier, Tunde ; Czirják, László ; Chizzolini, Carlo ; Allali, Danièle ; Zanatta, Elisabetta ; Doria, Andrea ; Gabrielli, Armando ; Airò, Paolo ; Lazzaroni, Maria-Grazia ; Radić, Mislav ; Martinovic, Duska ; Braun-Moscovici, Yolanda ; Balbir-Gurman, Alexandra ; Hunzelmann, Nicolas ; Caramaschi, Paola ; Morovic-Vergles, Jadranka ; Denton, Christopher ; Santamaria, Vera Ortiz ; Heitmann, Stefan ; Krasowska, Dorota ; Michalska-Jakubus, Malgorzata ; Seidel, Matthias ; Foeldvari, Ivan ; Helmus, Nicola ; Salvador, Maria João ; Stamenkovic, Bojana ; Stankovic, Aleksandra ; Ananieva, Lidia ; Herrick, Ariane ; Engelhart, Merete ; De La Puente, Carlos ; Hoffmann-Vold, Anna-Maria ; Midtvedt, Øyvind ; Launay, David ; Sobanski, Vincent ; Riccieri, Valeria ; Opris-Belinski, Daniela ; Groseanu, Laura ; Ionescu, Ruxandra Maria ; Bojinca, Mihai ; Sunderkötter, Cord ; Distler, Jörg ; Ingegnoli, Francesca ; van der Haecke, Amber ; Ullman, Susanne ; Pozzi, Maria Rosa ; Eyerich, Kilian ; Vanthuyne, Marie ; Erler, Anne ; Aringer, Martin ; De Langhe, Ellen ; Baresic, Marko ; Mayer, Miroslav ; Anic, Branimir ; Yavuz, Sule ; Granel, Brigitte ; Popa, Sergei ; Agachi, Svetlana ; Zenone, Thierry ; Mathieu, Alessandro ; Vacca, Alessandra ; Solanki, Kamal ; Veale, Douglas ; Loyo, Esthela ; Tineo, Carmen ; Gigante, Antonetta ; Rosato, Edoardo ; Oksel, Fahrettin ; Yagurcu, Figen ; Tănăseanu, Cristina-Mihaela ; Visalli, Elisa ; Benenati, Alessia ; Foti, Rosario ; Ancuta, Codrina ; Dan, Diana ; Adler, Sabine ; Villiger, Peter ; Fathi, Nihal ; de la Peña Lefebvre, Paloma García ; Martín, Jorge Juan González ; Chatelus, Emmanuel ; Sibilia, Jean ; Litinsky, Ira ; Del Galdo, Francesco ; Sakettkoo, Lesley Ann ; Kerzberg, Eduardo ; Bianchi, Washington A ; Bianchi, Breno Valdetaro ; Castellví, Ivan ; Limonta, Massimiliano ; Rimar, Doron ; Couto, Maura ; Ribi, Camillo ; Spertini, François ; Kahl, Sarah ; Hsu, Vivien ; Poindron, Vincent ; Meghit, Kilifa ; Martin, Thierry ; Kolstad, Kathleen ; Chung, Lorinda ; Thiele, Astrid ; Schmeiser, Tim ; Zdrojewski, Zbigniew ; Riemekasten, Gabriela ; Levy, Yair ; Cardoneanu, Anca ; Burlui, Alexandra ; Rezus, Elena ; Pamuk, Omer Nuri ; Talotta, Rossella ; Bongiovanni, Sara ; Puttini, Piercarlo Sarzi ; EUSTAR collaborators

Kolaboracija
EUSTAR

Izvornik
Rheumatology (1462-0324) 59 (2020), 8; 2016-2023

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
digital ulcers ; gangrene ; systemic sclerosis ; vasculopathy

Sažetak
Objective: In patients with SSc, peripheral vasculopathy can promote critical ischaemia and gangrene. The aim of this study was to investigate the prevalence, incidence and risk factors for gangrene in the EUSTAR cohort. Methods: We included patients from the EUSTAR database fulfilling the ACR 1980 or the ACR/EULAR 2013 classification criteria for SSc, with at least one visit recording data on gangrene. Centres were asked for supplementary data on traditional cardiovascular risk factors. We analysed the cross-sectional relationship between gangrene and its potential risk factors by univariable and multivariable logistic regression. Longitudinal data were analysed by Cox proportional hazards regression. Results: 1757 patients were analysed (age 55.9 [14.5] years, disease duration 7.9 [10.3] years, male sex 16.7%, 24.6% diffuse cutaneous subset [dcSSc]). At inclusion, 8.9% of patients had current or previous digital gangrene, 16.1% had current digital ulcers (DUs) and 42.7% had ever had DUs (current or previous). Older age, DUs ever and dcSSc were statistically significant risk factors for gangrene in the cross-sectional multivariable model. During a median follow-up of 13.1 months, 16/771 (0.9%) patients developed gangrene. All 16 patients who developed gangrene had previously had DUs and gangrene. Further risk factors for incident gangrene were the dcSSc subset and longer disease duration. Conclusion: In unselected SSc patients, gangrene occurs in about 9% of SSc patients. DUs ever and, to a lesser extent, the dcSSc subset are strongly and independently associated with gangrene, while traditional cardiovascular risk factors could not be identified as risk factors.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Split

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

(EUSTAR) Mihai, Carina; Distler, Oliver; Gheorghiu, Ana Maria; Constantin, Paul I; Dobrota, Rucsandra; Jordan, Suzana; Smith, Vanessa; Hachulla, Eric; Henes, Jörg; Siegert, Elise et al.
Incidence and risk factors for gangrene in patients with systemic sclerosis from the EUSTAR cohort // Rheumatology, 59 (2020), 8; 2016-2023 doi:10.1093/rheumatology/kez558 (međunarodna recenzija, članak, znanstveni)
(EUSTAR) (EUSTAR) Mihai, C., Distler, O., Gheorghiu, A., Constantin, P., Dobrota, R., Jordan, S., Smith, V., Hachulla, E., Henes, J. & Siegert, E. (2020) Incidence and risk factors for gangrene in patients with systemic sclerosis from the EUSTAR cohort. Rheumatology, 59 (8), 2016-2023 doi:10.1093/rheumatology/kez558.
@article{article, year = {2020}, pages = {2016-2023}, DOI = {10.1093/rheumatology/kez558}, keywords = {digital ulcers, gangrene, systemic sclerosis, vasculopathy}, journal = {Rheumatology}, doi = {10.1093/rheumatology/kez558}, volume = {59}, number = {8}, issn = {1462-0324}, title = {Incidence and risk factors for gangrene in patients with systemic sclerosis from the EUSTAR cohort}, keyword = {digital ulcers, gangrene, systemic sclerosis, vasculopathy} }
@article{article, year = {2020}, pages = {2016-2023}, DOI = {10.1093/rheumatology/kez558}, keywords = {digital ulcers, gangrene, systemic sclerosis, vasculopathy}, journal = {Rheumatology}, doi = {10.1093/rheumatology/kez558}, volume = {59}, number = {8}, issn = {1462-0324}, title = {Incidence and risk factors for gangrene in patients with systemic sclerosis from the EUSTAR cohort}, keyword = {digital ulcers, gangrene, systemic sclerosis, vasculopathy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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