hrvatski

Farmakogenomika hipolipemika: ABCG2 kao mogući prediktor hepatotoksičnosti

The ABCG2 protein is an active drug transporter across biological barriers, playing an important role in pharmacokinetics. Located on the intestinal, kidney and hepatic epithelial cells membranes, it enables substrate transport to the organ’s luminal side, acting as an efflux pump. Many drugs, known to be substrates/inhibitors of ABCG2, are recognized to be a relevant factor for the development of drug interactions and adverse events. The ABCG2 gene is polymorphic and its variant 421C>A, responsible for low activity, is presentin ~15% of Caucasians.

pharmacogenomics ; hypolipemics ; ABCG2

nije evidentirano

engleski

The pharmacogenomics of hypolipemics: ABCG2 as a potential predictor of hepatotoxicity

The ABCG2 protein is an active drug transporter across biological barriers, playing an important role in pharmacokinetics. Located on the intestinal, kidney and hepatic epithelial cells membranes, it enables substrate transport to the organ’s luminal side, acting as an efflux pump. Many drugs, known to be substrates/inhibitors of ABCG2, are recognized to be a relevant factor for the development of drug interactions and adverse events. The ABCG2 gene is polymorphic and its variant 421C>A, responsible for low activity, is presentin ~15% of Caucasians.

pharmacogenomics ; hypolipemics ; ABCG2

nije evidentirano