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Pregled bibliografske jedinice broj: 1084542

Chronic neurodegeneration and glial response following repetitive mild traumatic brain injury in the mouse optic tract are not affected by TDP-43 proteinopathy


Dolenec Petra, Pilipović Kristina, Rajič Bumber Jelena, Janković Tamara, Gržeta Nika, Križ Jasna, Župan Gordana
Chronic neurodegeneration and glial response following repetitive mild traumatic brain injury in the mouse optic tract are not affected by TDP-43 proteinopathy // FENS 2020 Virtual Forum of Neuroscience
Glasgow, Ujedinjeno Kraljevstvo, 2020. str. - (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1084542 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Chronic neurodegeneration and glial response following repetitive mild traumatic brain injury in the mouse optic tract are not affected by TDP-43 proteinopathy

Autori
Dolenec Petra, Pilipović Kristina, Rajič Bumber Jelena, Janković Tamara, Gržeta Nika, Križ Jasna, Župan Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FENS 2020 Virtual Forum of Neuroscience / - , 2020

Skup
FENS 2020 Virtual Forum of Neuroscience

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 11-15.07.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
repetitive traumatic brain injury, optic tract, neurodegeneration, glia, mouse

Sažetak
Aims: Preclinical and clinical studies suggest visual system vulnerability to damage following repetitive mild traumatic brain injury (rmTBI). Increasing evidence points to association between rmTBI and neurodegenerative diseases in which Tar DNA binding protein 43 (TDP-43) neuropathology was observed. The aim of this study was to investigate if rmTBI induces chronic neurodegeneration and glial response in the optic tracts of mice and does the genetic predisposition to TDP-43 proteinopathy influence it. Methods: Brain traumas were induced by the weight drop method, during five consecutive days, twice daily in wild type C57BL/6J (WT) and transgenic TDP-43G348C (TGTDP-43) adult mice. Mice of the control groups were anesthetized without receiving head impacts. Animals were sacrificed 6 months after the last procedure and their brains were prepared for the histological analyses. Fluoro-Jade C staining was used for detection of neurodegeneration, and immunofluorescent labeling of Iba1 and GFAP for microglia and astrocytes identification. Results: We found significantly increased Fluoro-Jade C intensity levels as well as the Iba1 and GFAP immunoreactivities in the optic tracts of traumatized mice of both genotypes in comparison to the related control groups, but the differences between the injured WT and TGTDP-43 animals were not detected. Conclusions: Our research suggests the presence of chronic degeneration and pronounced glial activity in the mouse optic tracts 6 months following rmTBI that was not additionally affected by genetically acquired TDP-43 dysregulation. This research was fully supported by the Croatian Science Foundation under project IP-2016-06-4602 to Ž.G.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-4602 - Blaga repetitivna traumatska ozljeda mozga: model za istraživanje neuropatologije i neuroupale posredovane s TDP-43 (TDP-43repTBI) (Župan, Gordana, HRZZ - 2016-06) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka


Citiraj ovu publikaciju

Dolenec Petra, Pilipović Kristina, Rajič Bumber Jelena, Janković Tamara, Gržeta Nika, Križ Jasna, Župan Gordana
Chronic neurodegeneration and glial response following repetitive mild traumatic brain injury in the mouse optic tract are not affected by TDP-43 proteinopathy // FENS 2020 Virtual Forum of Neuroscience
Glasgow, Ujedinjeno Kraljevstvo, 2020. str. - (poster, međunarodna recenzija, sažetak, znanstveni)
Dolenec Petra, Pilipović Kristina, Rajič Bumber Jelena, Janković Tamara, Gržeta Nika, Križ Jasna, Župan Gordana (2020) Chronic neurodegeneration and glial response following repetitive mild traumatic brain injury in the mouse optic tract are not affected by TDP-43 proteinopathy. U: FENS 2020 Virtual Forum of Neuroscience.
@article{article, year = {2020}, pages = {---}, keywords = {repetitive traumatic brain injury, optic tract, neurodegeneration, glia, mouse}, title = {Chronic neurodegeneration and glial response following repetitive mild traumatic brain injury in the mouse optic tract are not affected by TDP-43 proteinopathy}, keyword = {repetitive traumatic brain injury, optic tract, neurodegeneration, glia, mouse}, publisherplace = {Glasgow, Ujedinjeno Kraljevstvo} }
@article{article, year = {2020}, pages = {---}, keywords = {repetitive traumatic brain injury, optic tract, neurodegeneration, glia, mouse}, title = {Chronic neurodegeneration and glial response following repetitive mild traumatic brain injury in the mouse optic tract are not affected by TDP-43 proteinopathy}, keyword = {repetitive traumatic brain injury, optic tract, neurodegeneration, glia, mouse}, publisherplace = {Glasgow, Ujedinjeno Kraljevstvo} }




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