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Pregled bibliografske jedinice broj: 1083022

Variability of the DRB locus of MHC genes class II in red deer (Cervus elaphus) from a mountain region of Croatia


Bujanić, Miljenko; Bužan, Elena; Galov, Ana; Arbanasić, Haidi; Potušek, Sandra; Stipoljev, Sunčica; Šprem, Nikica; Križanović, Krešimir; Konjević, Dean
Variability of the DRB locus of MHC genes class II in red deer (Cervus elaphus) from a mountain region of Croatia // Veterinarski arhiv, 90 (2020), 4; 385-392 doi:10.24099/vet.arhiv.0862 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1083022 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Variability of the DRB locus of MHC genes class II in red deer (Cervus elaphus) from a mountain region of Croatia

Autori
Bujanić, Miljenko ; Bužan, Elena ; Galov, Ana ; Arbanasić, Haidi ; Potušek, Sandra ; Stipoljev, Sunčica ; Šprem, Nikica ; Križanović, Krešimir ; Konjević, Dean

Izvornik
Veterinarski arhiv (0372-5480) 90 (2020), 4; 385-392

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
red deer ; MHC genes ; DRB locus ; variability ; mountain region

Sažetak
Red deer (Cervus elaphus) are large indigenous mammals in Croatia. Even though Major Histocompatibility Complex (MHC) genes play a pivotal role in initiating immune response, there are no reports on their variability in red deer from Croatia. In this study, the variability of the DRB locus of MHC genes class II was analysed in 23 red deer from a mountain region of Croatia (Gorski Kotar). NGS sequencing revealed 23 unique DRB exon 2 sequences in 23 individuals, of which only six had been previously identified. The number of allelic variants per individual ranged from 1 to 6 (mean 3.09), with one individual having only one allele and one individual having all six allelic variants recognised. The most frequent allele, Ceel-DRB*HR01, was identified in 12 individuals (16.9%). The number of variable nucleotide sites was 84 (33.7%), and the number of variable amino acid positions in translated sequences was 44 (53%). The mean nucleotide evolutionary distance, based on the Jukes-Cantor model, with the gamma distribution shape parameter, was 16.5%, while the pairwise nucleotide distance ranged from 0.04% to 14.24%. The amino acid evolutionary distance, based on the Jones-Taylor-Thornton model, was 34.7%. Compared to the literature, it is clear that the mountain population of red deer from Croatia possesses considerable variability on the DRB locus, which is further confirmed by the notable nucleotide evolutionary distance.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Veterinarska medicina



POVEZANOST RADA


Projekti:
HRZZ-UIP-2013-11-3421 - Molekularna epidemiologija nekih invazijskih oboljenja divljih životinja (EpiMol) (Konjević, Dean, HRZZ - 2013-11) ( POIROT)
HRZZ-IP-2018-01-8963 - Interakcija nositelj-parazit: odnos tri različita tipa nositelja prema invaziji metiljem Fascioloides magna (MAGNA) (Konjević, Dean, HRZZ - 2018-01) ( POIROT)

Ustanove:
Fakultet elektrotehnike i računarstva, Zagreb,
Veterinarski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Agronomski fakultet, Zagreb

Citiraj ovu publikaciju

Bujanić, Miljenko; Bužan, Elena; Galov, Ana; Arbanasić, Haidi; Potušek, Sandra; Stipoljev, Sunčica; Šprem, Nikica; Križanović, Krešimir; Konjević, Dean
Variability of the DRB locus of MHC genes class II in red deer (Cervus elaphus) from a mountain region of Croatia // Veterinarski arhiv, 90 (2020), 4; 385-392 doi:10.24099/vet.arhiv.0862 (međunarodna recenzija, članak, znanstveni)
Bujanić, M., Bužan, E., Galov, A., Arbanasić, H., Potušek, S., Stipoljev, S., Šprem, N., Križanović, K. & Konjević, D. (2020) Variability of the DRB locus of MHC genes class II in red deer (Cervus elaphus) from a mountain region of Croatia. Veterinarski arhiv, 90 (4), 385-392 doi:10.24099/vet.arhiv.0862.
@article{article, year = {2020}, pages = {385-392}, DOI = {10.24099/vet.arhiv.0862}, keywords = {red deer, MHC genes, DRB locus, variability, mountain region}, journal = {Veterinarski arhiv}, doi = {10.24099/vet.arhiv.0862}, volume = {90}, number = {4}, issn = {0372-5480}, title = {Variability of the DRB locus of MHC genes class II in red deer (Cervus elaphus) from a mountain region of Croatia}, keyword = {red deer, MHC genes, DRB locus, variability, mountain region} }
@article{article, year = {2020}, pages = {385-392}, DOI = {10.24099/vet.arhiv.0862}, keywords = {red deer, MHC genes, DRB locus, variability, mountain region}, journal = {Veterinarski arhiv}, doi = {10.24099/vet.arhiv.0862}, volume = {90}, number = {4}, issn = {0372-5480}, title = {Variability of the DRB locus of MHC genes class II in red deer (Cervus elaphus) from a mountain region of Croatia}, keyword = {red deer, MHC genes, DRB locus, variability, mountain region} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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