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Pregled bibliografske jedinice broj: 108291

Products of Advanced Glycation in Diabetes and Vascular Disease


Turk, Zdenka; Šesto, Mihajlo; Skodlar, Jasna; Ferenčak, Goran; Turk, Nikša; Stavljenić-Rukavina, Ana
Products of Advanced Glycation in Diabetes and Vascular Disease // Clinical Chemistry & Laboratory Medicine / Siest, Gerard (ur.).
Berlin: Walter de Gruyter, 2002. str. S 99-S 99 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


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Naslov
Products of Advanced Glycation in Diabetes and Vascular Disease

Autori
Turk, Zdenka ; Šesto, Mihajlo ; Skodlar, Jasna ; Ferenčak, Goran ; Turk, Nikša ; Stavljenić-Rukavina, Ana

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Clinical Chemistry & Laboratory Medicine / Siest, Gerard - Berlin : Walter de Gruyter, 2002, S 99-S 99

Skup
The 18th International Congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Kioto, Japan, 20-25.10.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Diabetes; Coronary Artery Disease; Advanced Glycation; Antibody

Sažetak
Advanced glycation endproducts (AGE) and-AGE-antibodies in free and immune complex bound form (AGE-IC) were assayed in serum of diabetic (n=69) and nondiabetic patients (n=78) with coronary artery disease (CAD), and 47 controls matched for age and sex. A blocking ELISA was chosen to test immunoreactivity against AGE epitope(s), and competitive ELISA with polyclonal anti-AGE-antibodies was used to measure total AGE content. Soluble AGE-IC were detected by ELISA using an immunochemical bridge. Anti-AGE immunoreactivity was significantly (p<0.05) higher in diabetics than in controls. Although great dispersion of anti-AGE-antibody titre was observed in nondiabetic CAD patients, there was no significant difference from controls. Both, diabetic and nondiabetic CAD patients had higher amount of circulating AGE-IC than controls (p<0.01). Study patients showed positive correlatin between serum AGEs and AGE-IC (DM+CAD: r=0.3, p<0.01 ; CAD: r=0.26, p<0.01), whereas no correlation was recorded in controls. Circulating AGEs and anti-AGE antibodies in free or IC bound form were detected in serum of healthy subjects, and in higher amounts in both diabetic and nondiabetic CAD patients. It is possible that AGEs and anti-AGE IgG are naturally occurring products under homeostatic control. In pathophysiological conditions, however, the intensified glycoxidation of biological proteins may surpass the rate of scavenging.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0045003
0108247

Ustanove:
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Zdenka Turk (autor)

Avatar Url Nikša Turk (autor)

Avatar Url Goran Ferenčak (autor)

Avatar Url Ana Stavljenić (autor)

Avatar Url Mihajlo Šesto (autor)

Avatar Url Jasna Mesarić (autor)


Citiraj ovu publikaciju:

Turk, Zdenka; Šesto, Mihajlo; Skodlar, Jasna; Ferenčak, Goran; Turk, Nikša; Stavljenić-Rukavina, Ana
Products of Advanced Glycation in Diabetes and Vascular Disease // Clinical Chemistry & Laboratory Medicine / Siest, Gerard (ur.).
Berlin: Walter de Gruyter, 2002. str. S 99-S 99 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
Turk, Z., Šesto, M., Skodlar, J., Ferenčak, G., Turk, N. & Stavljenić-Rukavina, A. (2002) Products of Advanced Glycation in Diabetes and Vascular Disease. U: Siest, G. (ur.)Clinical Chemistry & Laboratory Medicine.
@article{article, editor = {Siest, G.}, year = {2002}, pages = {S 99-S 99}, keywords = {Diabetes, Coronary Artery Disease, Advanced Glycation, Antibody}, title = {Products of Advanced Glycation in Diabetes and Vascular Disease}, keyword = {Diabetes, Coronary Artery Disease, Advanced Glycation, Antibody}, publisher = {Walter de Gruyter}, publisherplace = {Kioto, Japan} }
@article{article, editor = {Siest, G.}, year = {2002}, pages = {S 99-S 99}, keywords = {Diabetes, Coronary Artery Disease, Advanced Glycation, Antibody}, title = {Products of Advanced Glycation in Diabetes and Vascular Disease}, keyword = {Diabetes, Coronary Artery Disease, Advanced Glycation, Antibody}, publisher = {Walter de Gruyter}, publisherplace = {Kioto, Japan} }




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