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Pregled bibliografske jedinice broj: 1082483

Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells


Cindrić, Anamarija; Penić-Ivanko, Laura; Mušković, Martina; Ratkaj, Ivana; Malatesti, Nela
Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells // 18. Ružičkini dani 2020 / Jukić, A. (ur.).
Zagreb i Osijek: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) Prehrambeno-tehnološki fakultet Osijek Sveučilišta J. J. Strosssmayera u Osijeku, 2020. str. 25-25 (poster, recenziran, sažetak, znanstveni)


CROSBI ID: 1082483 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells

Autori
Cindrić, Anamarija ; Penić-Ivanko, Laura ; Mušković, Martina ; Ratkaj, Ivana ; Malatesti, Nela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

ISBN
978-953-6894-75-8

Skup
18. Ružičkini dani 2020

Mjesto i datum
Vukovar, Hrvatska, 16-18.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
Photodynamic therapy ; Amphiphilic porphyrins ; Melanoma cell line

Sažetak
Melanomas are difficult to treat due to variety of resistance mechanisms, such as defects in apoptotic pathways, ABC transporters and melanin [1, 2]. Photodynamic therapy (PDT) shows some encouraging results against melanoma, thanks to multitarget mechanism of action [1]. Amphiphilic porphyrins have been widely investigated due to their possibility to pass through membrane, as well as being water soluble. Our research group has previously described activity of pyridylporphyrins on several cell lines, and amphiphilic porphyrins showed significantly higher PDT activity compared to their hydrophilic analogues [4]. Here we study the impact of conjugation of hydrophobic chains of various length within N- methylated and N-oxidised pyridylporphyrins. Physicochemical differences between groups are investigated on singlet oxygen production, stability, spectroscopic properties, and lipophilicity of the photosensitizers (PSs). Photodynamic activity will be evaluated on MEWO melanoma cell line by testing cytotoxicity and localization of the PSs inside cells.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Martina Mušković (autor)

Avatar Url Nela Malatesti (autor)

Avatar Url Ivana Ratkaj (autor)


Citiraj ovu publikaciju

Cindrić, Anamarija; Penić-Ivanko, Laura; Mušković, Martina; Ratkaj, Ivana; Malatesti, Nela
Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells // 18. Ružičkini dani 2020 / Jukić, A. (ur.).
Zagreb i Osijek: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) Prehrambeno-tehnološki fakultet Osijek Sveučilišta J. J. Strosssmayera u Osijeku, 2020. str. 25-25 (poster, recenziran, sažetak, znanstveni)
Cindrić, A., Penić-Ivanko, L., Mušković, M., Ratkaj, I. & Malatesti, N. (2020) Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells. U: Jukić, A. (ur.)18. Ružičkini dani 2020.
@article{article, editor = {Juki\'{c}, A.}, year = {2020}, pages = {25-25}, keywords = {Photodynamic therapy, Amphiphilic porphyrins, Melanoma cell line}, isbn = {978-953-6894-75-8}, title = {Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells}, keyword = {Photodynamic therapy, Amphiphilic porphyrins, Melanoma cell line}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI) Prehrambeno-tehnolo\v{s}ki fakultet Osijek Sveu\v{c}ili\v{s}ta J. J. Strosssmayera u Osijeku}, publisherplace = {Vukovar, Hrvatska} }
@article{article, editor = {Juki\'{c}, A.}, year = {2020}, pages = {25-25}, keywords = {Photodynamic therapy, Amphiphilic porphyrins, Melanoma cell line}, isbn = {978-953-6894-75-8}, title = {Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells}, keyword = {Photodynamic therapy, Amphiphilic porphyrins, Melanoma cell line}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI) Prehrambeno-tehnolo\v{s}ki fakultet Osijek Sveu\v{c}ili\v{s}ta J. J. Strosssmayera u Osijeku}, publisherplace = {Vukovar, Hrvatska} }




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