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Pregled bibliografske jedinice broj: 1082474

PDT potential of amphiphilic free-base and Zn(II) tripyridylporphyrins


Mušković, Martina; Ratkaj, Ivana; Malatesti, Nela
PDT potential of amphiphilic free-base and Zn(II) tripyridylporphyrins // 18. Ružičkini dani 2020. / Jukić, A. (ur.).
Zagreb i Osijek: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) Prehrambeno-tehnološki fakultet Osijek Sveučilišta J. J. Strosssmayera u Osijeku, 2020. str. 42-42 (poster, recenziran, sažetak, znanstveni)


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Naslov
PDT potential of amphiphilic free-base and Zn(II) tripyridylporphyrins

Autori
Mušković, Martina ; Ratkaj, Ivana ; Malatesti, Nela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

ISBN
978-953-6894-75-8

Skup
18. Ružičkini dani 2020.

Mjesto i datum
Vukovar, Hrvatska, 16-18.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
Amphiphilic porphyrins ; Cytotoxicity ; Lipophilicity ; Singlet oxygen production ; Zn(II) chelation

Sažetak
Photodynamic therapy (PDT) is a treatment modality used for malignant diseases where the combination of light, photosensitizer (PS) and molecular oxygen produces reactive oxygen species (ROS), which leads to cytotoxic effect and tumour destruction [1]. Characteristics of a good PS include good absorption of light in the red region of the spectrum, stability, negligible dark toxicity, and good production of singlet oxygen [1]. Increased production of singlet oxygen can be achieved by chelation with paramagnetic metals, such as zinc(II), since they increase the lifetime of the PS’s triplet state (3PS*)[2]. Lipophilicity also plays an important role in effectiveness of a PS in PDT. Hydrophobic moieties in PS facilitate passing through the membrane lipid bilayer, however, they reduce solubility in water and tend to aggregate. Hydrophilic moieties, on the other side, impair membrane penetration and cell internalization [3]. In this work, we investigate free-base, and Zn(II) chelated, amphiphilic tripyridylporphyrins, conjugated with chains of various length. Physiochemical properties of the prepared porphyrins will be analysed and compared. The relationship between these properties and PDT activity of the compounds will be shown using cytotoxicity test.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Martina Mušković (autor)

Avatar Url Nela Malatesti (autor)

Avatar Url Ivana Ratkaj (autor)


Citiraj ovu publikaciju

Mušković, Martina; Ratkaj, Ivana; Malatesti, Nela
PDT potential of amphiphilic free-base and Zn(II) tripyridylporphyrins // 18. Ružičkini dani 2020. / Jukić, A. (ur.).
Zagreb i Osijek: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) Prehrambeno-tehnološki fakultet Osijek Sveučilišta J. J. Strosssmayera u Osijeku, 2020. str. 42-42 (poster, recenziran, sažetak, znanstveni)
Mušković, M., Ratkaj, I. & Malatesti, N. (2020) PDT potential of amphiphilic free-base and Zn(II) tripyridylporphyrins. U: Jukić, A. (ur.)18. Ružičkini dani 2020..
@article{article, editor = {Juki\'{c}, A.}, year = {2020}, pages = {42-42}, keywords = {Amphiphilic porphyrins, Cytotoxicity, Lipophilicity, Singlet oxygen production, Zn(II) chelation}, isbn = {978-953-6894-75-8}, title = {PDT potential of amphiphilic free-base and Zn(II) tripyridylporphyrins}, keyword = {Amphiphilic porphyrins, Cytotoxicity, Lipophilicity, Singlet oxygen production, Zn(II) chelation}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI) Prehrambeno-tehnolo\v{s}ki fakultet Osijek Sveu\v{c}ili\v{s}ta J. J. Strosssmayera u Osijeku}, publisherplace = {Vukovar, Hrvatska} }
@article{article, editor = {Juki\'{c}, A.}, year = {2020}, pages = {42-42}, keywords = {Amphiphilic porphyrins, Cytotoxicity, Lipophilicity, Singlet oxygen production, Zn(II) chelation}, isbn = {978-953-6894-75-8}, title = {PDT potential of amphiphilic free-base and Zn(II) tripyridylporphyrins}, keyword = {Amphiphilic porphyrins, Cytotoxicity, Lipophilicity, Singlet oxygen production, Zn(II) chelation}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI) Prehrambeno-tehnolo\v{s}ki fakultet Osijek Sveu\v{c}ili\v{s}ta J. J. Strosssmayera u Osijeku}, publisherplace = {Vukovar, Hrvatska} }




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