Estimation of inbreeding and effective population size in Simmental cattle using genomic information (CROSBI ID 694331)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Karapandža, Nina ; Curik, Ino ; Špehar, Marija ; Ferenčaković, Maja
engleski
Estimation of inbreeding and effective population size in Simmental cattle using genomic information
Precise estimates of effective population size and a degree of inbreeding are of great importance for population and conservation genetics. Experience has shown that estimates based on pedigree data are often unreliable and imprecise. High resolute genomic information, as one of the most polymorphic types of information, was highlighted as much more precise for this kind of calculations. In this research, we used genotypes of 107 Simmental young animals. Dual purpose Simmental breed represents dominant part of Croatian cattle population (62.8%) under selection scheme. Effective population size (Ne) was estimated based on a functional relationship of Ne and correlation r2 and recombination rate (c). To estimate Ne through generations we used a multithreaded tool SNeP. Regression analysis was used to estimate current effective population size, and a value of Ne=110 (95%CI: 101.98-118.02) was obtained. Historical estimates of the Ne during the last 100 generations showed linear decrease of 29.24 per generation. We also estimated inbreeding levels based on runs of homozygosity (ROH) for every animal. Averaged values were as follows: FROH1=0.026 (0.015-0.045), FROH2=0.01 (0.004- 0.019), FROH4=0.002 (0-0.006) while we did not detect any inbreeding originating from up to 6.25 generations ago. ROH and LD calculations were done by PLINK while data manipulation, regression analysis and visualizations were done using SAS 9.4. For comparison, we calculated Ne based on pedigree information using ENDOG software, which computes Ne via individual increase in inbreeding. For a population of 107 genotyped animals we obtained a value of 229.18, and for the population of 682 bulls that are of great importance for artificial insemination value of 264.92. Mean inbreeding was 0.42 and 0.27%. We can conclude that genomic nformation will be very useful to understand genetic diversity of the Simmental population with respect to genetic selection. In addition, it will help to identify genomic regions which have been preferentially selected
inbreeding, effective population size, simmental cattle
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Podaci o prilogu
125-125.
2018.
objavljeno
Podaci o matičnoj publikaciji
Book of Abstracts of the 69th Annual Meeting of the European Federation of Animal Science
Podaci o skupu
69th Annual Meeting of the European Federation of Animal Science (EAAP)
poster
27.08.2018-31.08.2018
Dubrovnik, Hrvatska