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Effects of dopaminergic drugs on inflammatory bowel disease induced with 2, 4-dinitrofluorbenzene in BALB/c mice (CROSBI ID 98979)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Herak-Perković, Vlasta ; Grabarević, Željko ; Banić, Marko ; Anić, Branimir ; Novosel, Vesna ; Pogačnik, Milan Effects of dopaminergic drugs on inflammatory bowel disease induced with 2, 4-dinitrofluorbenzene in BALB/c mice // Journal of Veterinary Pharmacology and Therapeutics, 24 (2001), 4; 267-273. doi: 10.1046/j.1365-2885.2001.00343.x

Podaci o odgovornosti

Herak-Perković, Vlasta ; Grabarević, Željko ; Banić, Marko ; Anić, Branimir ; Novosel, Vesna ; Pogačnik, Milan

engleski

Effects of dopaminergic drugs on inflammatory bowel disease induced with 2, 4-dinitrofluorbenzene in BALB/c mice

The aim of the study was to demonstrate the effects of dopaminergic drugs on 2, 4- dinitrofluorbenzene (DNFB) induced experimental inflammatory bowel disease (IBD) in previously sensitised BALB/c mice. The number and extent of ulcerations and erosions, the intensity of haeomorrhages, edema, and accumulation of neutrophils and eosinophils within colonic lamina propria and submucosa were scored and statistically evaluated. The 180 BALB/c mice, were allocated into three equal groups. The mice in the first experimental group were treated with domperidone (DP), a peripheral dopamine (DA) antagonist. The mice from the second experimental group were treated with bromocriptine (BC), a dopamine agonist. The mice from the control group were treated with an equivalent volume of normal saline in the same manner. Ten animals from each group were killed on days 1, 2, 3, 5, and 10, subsequent to the challenge enema of the DNFB solution. Gross and microscopic examination of the colon was performed. Treatment with BC resulted in clinical improvement and decreased mortality rate by 2 of 60 (3%), while domperidone treatment increased mortality rate to 12 of 60 (20%) compared with the controls (4 of 60 /6%/). The nalysis of the microscopic lesions indicated that the beneficial effects of BC were the result of maintenance of vascular integrity.

induced gastric-ulcers ; therapeutic applications ; animal-model ; agonists ; rats ; stomach ; bromocriptine

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Podaci o izdanju

24 (4)

2001.

267-273

objavljeno

0140-7783

10.1046/j.1365-2885.2001.00343.x

Povezanost rada

Veterinarska medicina

Poveznice
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