Involvement of T lymphocytes in the placentae with villitis of unknown etiology from pregnancies complicated with preeclampsia (CROSBI ID 283601)
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Podaci o odgovornosti
Benzon, Sandra ; Zekić Tomaš, Sandra ; Benzon, Zdeslav ; Vulić, Marko ; Kuzmić Prusac, Ivana
engleski
Involvement of T lymphocytes in the placentae with villitis of unknown etiology from pregnancies complicated with preeclampsia
Translator disclaimer Abstract Objective: The aim of the study was to compare immunohistochemical expression of different T type lymphocytes in foci of villitis of placentae with villitis of unknown etiology (VUE) without and with preeclampsia (PE). Methods: Fifty-four placentae were collected from women who had VUE with (N = 27) and without (N = 27) PE. Immunohistochemistry for types of T lymphocytes was performed on formalin fixed and paraffin-embedded sections by use of the CD3, CD4, FOXP3, CD25, CD8 and CD68 antibodies. All data analyses were done by R Development Core Team. Results: There was higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE compared to control group. Conclusion: The higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE could point to their role in ethiopathogenesis of PE.
Preeclampsia, T lymphocytes, villitis of unknown etiology
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Podaci o izdanju
29 (7)
2015.
1055-1060
objavljeno
1476-7058
10.3109/14767058.2015.1032239
Povezanost rada
Temeljne medicinske znanosti