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Pregled bibliografske jedinice broj: 1081242

Fluorimetric and CD Recognition Between Various ds-DNA/RNA Depends on a Cyanine Connectivity in Cyanine-guanidiniocarbonyl-pyrrole Conjugate


Šmidlehner, Tamara; Košćak, Marta; Božinović, Ksenija; Majhen, Dragomira; Schmuck, Carsten; Piantanida, Ivo
Fluorimetric and CD Recognition Between Various ds-DNA/RNA Depends on a Cyanine Connectivity in Cyanine-guanidiniocarbonyl-pyrrole Conjugate // Molecules, 25 (2020), 4470, 14 doi:10.3390/molecules25194470 (međunarodna recenzija, članak, znanstveni)


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Naslov
Fluorimetric and CD Recognition Between Various ds-DNA/RNA Depends on a Cyanine Connectivity in Cyanine-guanidiniocarbonyl-pyrrole Conjugate

Autori
Šmidlehner, Tamara ; Košćak, Marta ; Božinović, Ksenija ; Majhen, Dragomira ; Schmuck, Carsten ; Piantanida, Ivo

Izvornik
Molecules (1420-3049) 25 (2020); 4470, 14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cyanine dyes ; guanidiniocarbonyl-pyrrole ; ds-DNA/RNA sensing ; fluorescence ; circular dichroism ; mitochondria

Sažetak
Two novel isosteric conjugates of guanidiniocarbonyl-pyrrole and 6-bromo-TO (thiazole orange) were prepared, differing only in linker connectivity to cyanine (benzothiazole nitrogen vs. quinoline nitrogen). The quinoline analog was significantly more susceptible to aggregation in an aqueous medium, which resulted in induced circular dichroism (ICD ; λ = 450–550 nm) recognition between A-T(U) and G-C basepair containing polynucleotides. The benzothiazole-isostere showed pronounced (four-fold) fluorimetric selectivity toward ds-RNA in comparison to any ds-DNA, at variance to its quinoline-analogue fluorescence being weakly selective to GC-DNA. Preliminary screening on human tumor and normal lung cell lines showed that both dyes very efficiently enter living cells and accumulate in mitochondria, causing moderate cytotoxic effects, and thus could be considered as lead compounds toward novel theragnostic mitochondrial dyes.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA/RNA sekundarne strukture molekularnim kemijskim senzorima (DNA/RNA-MolSense) (Piantanida, Ivo, HRZZ - 2013-11) ( POIROT)
HRZZ-IP-2018-01-5475 - Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina (BioMultiChromoProbes) (Piantanida, Ivo, HRZZ - 2018-01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Šmidlehner, Tamara; Košćak, Marta; Božinović, Ksenija; Majhen, Dragomira; Schmuck, Carsten; Piantanida, Ivo
Fluorimetric and CD Recognition Between Various ds-DNA/RNA Depends on a Cyanine Connectivity in Cyanine-guanidiniocarbonyl-pyrrole Conjugate // Molecules, 25 (2020), 4470, 14 doi:10.3390/molecules25194470 (međunarodna recenzija, članak, znanstveni)
Šmidlehner, T., Košćak, M., Božinović, K., Majhen, D., Schmuck, C. & Piantanida, I. (2020) Fluorimetric and CD Recognition Between Various ds-DNA/RNA Depends on a Cyanine Connectivity in Cyanine-guanidiniocarbonyl-pyrrole Conjugate. Molecules, 25, 4470, 14 doi:10.3390/molecules25194470.
@article{article, year = {2020}, pages = {14}, DOI = {10.3390/molecules25194470}, chapter = {4470}, keywords = {cyanine dyes, guanidiniocarbonyl-pyrrole, ds-DNA/RNA sensing, fluorescence, circular dichroism, mitochondria}, journal = {Molecules}, doi = {10.3390/molecules25194470}, volume = {25}, issn = {1420-3049}, title = {Fluorimetric and CD Recognition Between Various ds-DNA/RNA Depends on a Cyanine Connectivity in Cyanine-guanidiniocarbonyl-pyrrole Conjugate}, keyword = {cyanine dyes, guanidiniocarbonyl-pyrrole, ds-DNA/RNA sensing, fluorescence, circular dichroism, mitochondria}, chapternumber = {4470} }
@article{article, year = {2020}, pages = {14}, DOI = {10.3390/molecules25194470}, chapter = {4470}, keywords = {cyanine dyes, guanidiniocarbonyl-pyrrole, ds-DNA/RNA sensing, fluorescence, circular dichroism, mitochondria}, journal = {Molecules}, doi = {10.3390/molecules25194470}, volume = {25}, issn = {1420-3049}, title = {Fluorimetric and CD Recognition Between Various ds-DNA/RNA Depends on a Cyanine Connectivity in Cyanine-guanidiniocarbonyl-pyrrole Conjugate}, keyword = {cyanine dyes, guanidiniocarbonyl-pyrrole, ds-DNA/RNA sensing, fluorescence, circular dichroism, mitochondria}, chapternumber = {4470} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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