Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia (CROSBI ID 694179)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Glodić, Goran ; Sabol, Ivan ; Žmak, Ljiljana ; Šola, Ana Marija ; Marušić, Ante ; Hećimović, Ana ; Džubur, Feđa ; Jakopović, Marko ; Kardum Bulat, Ljiljana ; Pavliša, Gordana ; Samaržija, Miroslav ; Čivljak, Antonija ; Dakić, Antonija ; Janković Makek, Mateja
engleski
Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia
Introduction: Clinical differences between M. avium and M. intracellulare haven't been fully studied. Aims and objectives: to asses the relevance of M. avium complex (MAC) members ; record treatment outcomes and long term survival of MAC pulmonary disease (MAC-PD) patients. Methods: retrospective study on all Croatian residents with MAC respiratory isolates from 2006 to 2016 with follow up to 2018. ATS/IDSA guidelines were used to establish MAC-PD and evaluate treatment adequacy. Results: Medical records were available for 93/149 (62.4%) isolates. MAC-PD was diagnosed in 36/49 73.4%) of M. avium and 24/44 (54.5%) of M. intracellulare isolates. Fibrocavitary form and smear positivity were more common with M. intracellulare than M. avium - 33.3 vs. 22.2% and 61 vs. 27.6%, respectively. Treatment was started in 23/36 (63.9%) of M. avium and 21/23 (91.3%) of M. intracellulare. Adequate regimen was administered in 26.1% (6/23) of M. avium and 55% (11/20) of M.intracellulare patients, and microbiological cure was achieved in 83.3% and 72.7% of cases, respectively. One-year mortality of M. avium patients was 19.4% compared to 8.3% of M. intracellulare. 5-year all-cause mortality amounted to 36% and 30% of M. avium and M. intracellulare cases, respectively (p=0.876). Conclusions: M. avium showed a higher percentage of isolates meeting the MAC-PD criteria. Still, M.intracellulare disease was more severe in its presentation, which partly explains the higher rate and adequacy of treatment. Although one-year mortality of M. avium cases was doubled compared to M. intracellulare, there were no differences in long term survival between the two groups.
treatments ; bacteria ; orphan diseases
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Podaci o prilogu
PA3002
2019.
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objavljeno
10.1183/13993003.congress-2019.pa3002
Podaci o matičnoj publikaciji
The European respiratory journal
0903-1936
1399-3003
Podaci o skupu
29th ERS International congress
poster
28.09.2019-02.10.2019
Madrid, Španjolska
Povezanost rada
Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti