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Pregled bibliografske jedinice broj: 1081195

Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia


Glodić, Goran; Sabol, Ivan; Žmak, Ljiljana; Šola, Ana Marija; Marušić, Ante; Hećimović, Ana; Džubur, Feđa; Jakopović, Marko; Kardum Bulat, Ljiljana; Pavliša, Gordana et al.
Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia // European Respiratory Journal
Madrid, Španjolska: European Respiratory Society, 2019. PA3002, 1 doi:10.1183/13993003.congress-2019.pa3002 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1081195 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia

Autori
Glodić, Goran ; Sabol, Ivan ; Žmak, Ljiljana ; Šola, Ana Marija ; Marušić, Ante ; Hećimović, Ana ; Džubur, Feđa ; Jakopović, Marko ; Kardum Bulat, Ljiljana ; Pavliša, Gordana ; Samaržija, Miroslav ; Čivljak, Antonija ; Dakić, Antonija ; Janković Makek, Mateja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Respiratory Journal / - : European Respiratory Society, 2019

Skup
29th ERS International Congress

Mjesto i datum
Madrid, Španjolska, 28.09-02.10.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Treatments ; Bacteria ; Orphan diseases

Sažetak
Introduction: Clinical differences between M. avium and M. intracellulare haven't been fully studied. Aims and objectives: to asses the relevance of M. avium complex (MAC) members ; record treatment outcomes and long term survival of MAC pulmonary disease (MAC-PD) patients. Methods: retrospective study on all Croatian residents with MAC respiratory isolates from 2006 to 2016 with follow up to 2018. ATS/IDSA guidelines were used to establish MAC-PD and evaluate treatment adequacy. Results: Medical records were available for 93/149 (62.4%) isolates. MAC-PD was diagnosed in 36/49 73.4%) of M. avium and 24/44 (54.5%) of M. intracellulare isolates. Fibrocavitary form and smear positivity were more common with M. intracellulare than M. avium - 33.3 vs. 22.2% and 61 vs. 27.6%, respectively. Treatment was started in 23/36 (63.9%) of M. avium and 21/23 (91.3%) of M. intracellulare. Adequate regimen was administered in 26.1% (6/23) of M. avium and 55% (11/20) of M.intracellulare patients, and microbiological cure was achieved in 83.3% and 72.7% of cases, respectively. One-year mortality of M. avium patients was 19.4% compared to 8.3% of M. intracellulare. 5-year all-cause mortality amounted to 36% and 30% of M. avium and M. intracellulare cases, respectively (p=0.876). Conclusions: M. avium showed a higher percentage of isolates meeting the MAC-PD criteria. Still, M.intracellulare disease was more severe in its presentation, which partly explains the higher rate and adequacy of treatment. Although one-year mortality of M. avium cases was doubled compared to M. intracellulare, there were no differences in long term survival between the two groups.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Klinički bolnički centar Rijeka

Citiraj ovu publikaciju

Glodić, Goran; Sabol, Ivan; Žmak, Ljiljana; Šola, Ana Marija; Marušić, Ante; Hećimović, Ana; Džubur, Feđa; Jakopović, Marko; Kardum Bulat, Ljiljana; Pavliša, Gordana et al.
Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia // European Respiratory Journal
Madrid, Španjolska: European Respiratory Society, 2019. PA3002, 1 doi:10.1183/13993003.congress-2019.pa3002 (poster, međunarodna recenzija, sažetak, znanstveni)
Glodić, G., Sabol, I., Žmak, L., Šola, A., Marušić, A., Hećimović, A., Džubur, F., Jakopović, M., Kardum Bulat, L. & Pavliša, G. (2019) Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia. U: European Respiratory Journal doi:10.1183/13993003.congress-2019.pa3002.
@article{article, year = {2019}, pages = {1}, DOI = {10.1183/13993003.congress-2019.pa3002}, chapter = {PA3002}, keywords = {Treatments, Bacteria, Orphan diseases}, doi = {10.1183/13993003.congress-2019.pa3002}, title = {Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia}, keyword = {Treatments, Bacteria, Orphan diseases}, publisher = {European Respiratory Society}, publisherplace = {Madrid, \v{S}panjolska}, chapternumber = {PA3002} }
@article{article, year = {2019}, pages = {1}, DOI = {10.1183/13993003.congress-2019.pa3002}, chapter = {PA3002}, keywords = {Treatments, Bacteria, Orphan diseases}, doi = {10.1183/13993003.congress-2019.pa3002}, title = {Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia}, keyword = {Treatments, Bacteria, Orphan diseases}, publisher = {European Respiratory Society}, publisherplace = {Madrid, \v{S}panjolska}, chapternumber = {PA3002} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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