engleski

Synthesis of phenanthridine-based calix[4]arene glycoconjugate and physicochemical characterization of its complexation reactions with alkali metal cations

Calixarenes are a class of supramolecular hosts consisted of phenolic residues linked by methylene bridges in the ortho position. They can be easily functionalized to give receptors for various ionic and/or neutral species. Calixarene amide derivatives have very high affinities towards alkali metal cations, and can be glycosylated to produce water-soluble compounds. In the scope of this work, fluorescent, phenanthridine-based calix[4]arene glycoconjugate was synthesized. The affinity of this ligand towards alkali metal cations was investigated by means of spectrophotometry, fluorimetry, microcalorimetry, and 1H NMR spectroscopy. From the obtained results, stability constants of the complexes formed, as well as the corresponding standard Gibbs energies, enthalpies and entropies were calculated and discussed.

calix[4]arene ; phenantridine ; alkali metal cation ; fluorescence

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