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Cytokines produced by human B cells enable them to maintain rather than establish T helper cell responses (CROSBI ID 488611)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Gagro, Alenka ; Toellner, K M ; Servis, Dražen ; Grafton, G ; Gordon, John Cytokines produced by human B cells enable them to maintain rather than establish T helper cell responses // Scandinavian Journal of Immunology 54, (Suppl 1). 2001. str. 32-32-x

Podaci o odgovornosti

Gagro, Alenka ; Toellner, K M ; Servis, Dražen ; Grafton, G ; Gordon, John

engleski

Cytokines produced by human B cells enable them to maintain rather than establish T helper cell responses

B cells, in their resting state, lack antigen presentation capacity, but shortly after crosslinking of their Ig and/or ligation of CD40, they upregulate B7 molecules and differentiate into efficient antigen presenting cells (APC). The recent finding that murine naive B cells differentiate into effector subsets 1 and 2, which produce Th1- and Th2-associated cytokines, respectively, has suggested that B cells have the capacity to amplify or maintain an ongoing polarized immune responses. We have shown previously that exogenous IL-12 induced IFN-gamma production in human B cells on engaging CD40.Here we compared human naive (CD27-ve) and memory (CD27+ve cells) tonsilar B cells for their expression of the major Th1 polarising cytokine, IL-12, and signals that induce this cytokine. We found that, in contrast to dendritic cells, CD40 ligation in the presence of IFN-gamma, did not induce IL-12 secretion in either naive or memory B cells (determined by ELISA and intracellular cytokine staining) although both freshly isolated and in vitro stimulated populations expressed mRNA for p40 IL-12. The inability of B cells to produce IL-12 would limit their capacity as first line APC for the initiation of Th1 responses. However, their capacity to produce IFN-gamma within a Th1-priming environment offers B cells the potential to maintain and amplify this direction of skewing

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Podaci o prilogu

32-32-x.

2001.

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objavljeno

Podaci o matičnoj publikaciji

Scandinavian Journal of Immunology 54, (Suppl 1)

Podaci o skupu

11th International Congress of Immunology

predavanje

22.07.2001-27.07.2001

Stockholm, Švedska

Povezanost rada

Temeljne medicinske znanosti