engleski

Expression of activated microglia cells markers IBA1, CD68, and HLA-DR in the hippocampal formation of patients with Alzheimer's disease

Numerous studies have documented that uncontrolled immune response in the brain contributes to the progression of Alzheimer's disease (AD). The main goal of this study was to analyzed the expression of microglia cells markers IBA1, CD68, and HLA-DR in the different areas of the hippocampal formation (granular cell layer of dentate gyrus, hilus, CA2/3, CA1, subiculum, and white matter) of patients with AD and control samples. The results showed positive correlation between the expression of activated microglia cells markers CD68 and HLA-DR with AD. However, IBA1 was negatively correlated with AD. These results support the inflammatory hypothesis of AD and suggest that the aberrant microglial response might be crucial for the development and progression of all neuropathological changes seen in AD.

Alzheimer's disease ; hippocampal formation ; microglia ; neuroinflammation ; pro-inflammatory markers

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