Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Dissolution kinetics of copper nanoparticles in model physiological fluids and dynamics of copper(ii) complexes with chiral amino acids (CROSBI ID 694074)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Jurković, Lara ; Hazdovac, Ivana ; Maltar-Strmečki, Nadica ; Mark Lyons, Daniel Dissolution kinetics of copper nanoparticles in model physiological fluids and dynamics of copper(ii) complexes with chiral amino acids // Adriatic NMR: Book of Abstract. 2020. str. 40-40

Podaci o odgovornosti

Jurković, Lara ; Hazdovac, Ivana ; Maltar-Strmečki, Nadica ; Mark Lyons, Daniel

engleski

Dissolution kinetics of copper nanoparticles in model physiological fluids and dynamics of copper(ii) complexes with chiral amino acids

Metallic nanoparticles have attracted huge attention in biomedical applications due to their unique size-dependent properties, in particular copper nanoparticles because of their anti-bacterial, anti-fungal, anti- inflammatory and anti-proliferative properties [1]. However, the potential for interactions with non-targeted healthy cells, especially as copper nanoparticles may undergo a range of chemical transformations in the body, represents a still unresolved issue. In particular, the quantity and rate of copper nanoparticle dissolution in bodily fluids and tissue, with release of ionic Cu2+, may represent a key step in the pharmacokinetics and potential toxicity of such nanomaterials. Thus, we report herein an analysis of the physicochemical properties and dissolution kinetics of copper nanoparticles in saline solution in the presence of bovine serum albumin as a simplified model for blood plasma. Further, as copper(II) complexes with amino acids serve as models for metalloproteins and transport in a wide range of important biological processes, we have subsequently investigated the nanoparticle-released Cu2+ in terms of the dynamical behavior of copper(II) bis-complexes with selected chiral amino acids (nonpolar, polar and electrically charged). The complexes were studied by electron paramagnetic resonance (EPR) spectroscopy with the presence of the cis and trans isomers determined for both L- and D- enantiomers [2]. The influence of this chirality on the rotational motion of the Cu(II)-amino acid complexes was also examined. These results will help in resolving transformation pathways, behaviour and safety of metallic nanoparticles in physiological fluids as their application in biomedicine becomes more widespread.

EPR ; copper nanoparticles ; kinetics ; amino acids

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

40-40.

2020.

objavljeno

Podaci o matičnoj publikaciji

Adriatic NMR: Book of Abstract

Podaci o skupu

Adriatic NMR

poster

22.09.2020-24.09.2020

Peroj, Hrvatska

Povezanost rada

Fizika, Interdisciplinarne biotehničke znanosti, Interdisciplinarne prirodne znanosti, Kemija