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Synthesis and antioxidative activity of novel N- substituted benzimidazole carboxamides

A variety of biochemical processes in the human body could produce oxygen free radicals and other reactive oxygen species (ROS) as by- products which may cause oxidative damage of most important biomolecules such as nucleic acids, lipids and proteins. There has been tremendous and constant growing interest for the searching of novel natural or synthetic organic molecules as potential antioxidants. Heterocycles like benzimidazole derivatives can be promising candidates as antioxidants as these compounds are reported to exhibit a wide range of biological activity [1]. In this work, we present the synthesis of a range of N-substituted benzimidazole-2- carboxamides with a variable number of methoxy groups using conventional organic synthetic methods. Starting from the corresponding benzoyl-chlorides, in the reaction with N-substituted 2-aminobenzimidazoles carboxamides were obtained in moderate reaction yields [2]. Their antioxidative potency has been evaluated using 1, 1-diphenyl-picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) assays.

amides, antioxidative activity, benzimidazoles, carboxamides, organic synthesis

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