engleski

Choline chloride based deep eutectic solvents as suitable green media for synthesis of coumarinyl Schiff bases

Coumarin and its derivatives as highly bioactive heterocycles possess a wide range of biological, pharmacological, biochemical and therapeutic properties, which are strongly structure dependent. Schiff bases bearing coumarin moiety in conjunction with imino group (-C=N-), form a significant compounds in medicinal and pharmaceutical chemistry [1]. Deep eutectic solvents (DESs) have proven to be a suitable media for many synthetic pathways. DESs are often described as green mixtures, whose properties can be adjusted for various applications using different molar ratios of initial components [2]. The aim of this study was to synthesize coumarinyl Schiff bases utilizing ChCl-based DES as a reaction media and a catalyst, as well. Hereby, we applied an environmentally friendly approach, utilizing a solvent made of biodegradable components, with low toxicity and vapor pressure, which can be easily recycled and reused [3]. DESs are proven the excellent media for all these reactions, while the isolation of the final product was easy, and included the addition of water and filtration.

deep eutectic solvents ; coumarin; Schiff base

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