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The "BioPhyMeTRE" project: novel biological and physical methods for triage in radiological and nuclear (R/N) emergencies

Introduction: The project entitled “Novel biological and physical methods for triage in radiological and nuclear (R/N) emergencies” (BioPhyMeTRE) has been recently approved within the NATO Science for Peace and Security Programme. The project focuses on innovative biological and physical dosimetry methods allowing a rapid screening/triage of potential victims by using inexpensive and user- friendly analytical procedures and devices. Methods: In the “BioPhyMeTRE” project, a multi- parametric approach, by both biological and physical dosimetry methods, is used. The biological method combines the two most standardised biodosimetry methods into a more exhaustive “two-in-one” assay. The physical method focuses on the use of a low cost, portable mini photo-luminescence reader for the individual dose assessment by using personal objects. Results: The novel biological and physical methods have been developed and partially tested by the laboratories participating in the project. The biological combined protocol offers the advantage of simultaneous scoring of chromosome aberrations and micronuclei on the same slide, it is therefore time-saving and inexpensive. The physical method system, designed and commercialized for irradiated food analysis, allows rapid measurements, is transportable and usable in site, even by not skilled operators. Both methods will be validated through the set- up of calibration curves and inter-laboratory comparisons to verify their reliability for triage in R/N emergencies. Moreover, automation systems for the novel biological protocol will be evaluated. Conclusion: The biological and physical dosimetry methods proposed in the “BioPhyMeTRE” project, once they have been fully developed and validated, could represent useful tools for the categorization of subjects overexposed to ionising radiation in R/N emergencies.

retrospective dosimetry ; physical dosimetry ; biodosimetry

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