engleski

Developmental and degenerative deficiencies in the language network A sibling story

The story of a hereditary vulnerability of the left hemisphere language network as the basis for both developmental and degenerative language deficits has been unfolding for some time. It has long been recognized that developmental dyslexia and other developmental language impairments can reflect cortical anomalies in the left hemisphere, including the planum temporale.1 A genetic basis for some developmental language disorders such as FOXP2 mutations was also identified nearly 2 decades ago.2 We have also known for some time that people with the neurodegenerative language disorder of primary progressive aphasia (PPA) have cortical atrophy in the left hemisphere.3 But a link between developmental and neurodegenerative language deficits has been discovered more recently, 4, 5 and a FOXP2-driven network has recently been implicated in both developmental and neurodegenerative disease.6

Aphasia ; Cognitive Disorders ; Dyslexia

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