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Pregled bibliografske jedinice broj: 1077115

P267 The S2PLIT-UG score, a novel system identifying patients with a high risk of all- cause mortality following acute decompensation of heart failure, correlates with levels of sST2, hs-cTnI and NT-proBNP


(CATSTAT-HF) Borovac, Josip Anđelo; D'Amario, Domenico; Glavaš, Duška; Sušilović Grabovac, Zora; Šupe Domić, Daniela; Novak, Katarina; Bradarić, Anteo; Miličić, Davor; Duplančić, Darko; Božić, Joško
P267 The S2PLIT-UG score, a novel system identifying patients with a high risk of all- cause mortality following acute decompensation of heart failure, correlates with levels of sST2, hs-cTnI and NT-proBNP // European Journal of Heart Failure, 22 (2020), S1; 27-28 doi:10.1002/ejhf.1963 (međunarodna recenzija, ostalo)


CROSBI ID: 1077115 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
P267 The S2PLIT-UG score, a novel system identifying patients with a high risk of all- cause mortality following acute decompensation of heart failure, correlates with levels of sST2, hs-cTnI and NT-proBNP

Autori
Borovac, Josip Anđelo ; D'Amario, Domenico ; Glavaš, Duška ; Sušilović Grabovac, Zora ; Šupe Domić, Daniela ; Novak, Katarina ; Bradarić, Anteo ; Miličić, Davor ; Duplančić, Darko ; Božić, Joško

Kolaboracija
CATSTAT-HF

Izvornik
European Journal of Heart Failure (1388-9842) 22 (2020), S1; 27-28

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ostalo, ostalo

Ključne riječi
S2PLIT-UG score ; inflammation ; adverse ; ventricular remodeling ; fibrosis ; ventricular dysfunction ; LV ; sST2 ; hs-cTnI ; myocardial injury ; troponin ; soluble suppression of tumorigenicity 2 ; NT-proBNP ; natriuretic peptides

Sažetak
Background: The S2PLIT‐UG score has been recently published as a risk stratification tool for 1‐year all‐cause mortality among patients discharged after an acute decompensated heart failure (ADHF) event. This score stratifies ADHF patients into low, intermediate and high‐risk categories. It is calculated by combining 6 variables collected at admission including estimated glomerular filtration rate, uric acid, left ventricular ejection fraction, sodium, systolic blood pressure and the history of heart failure‐ related hospitalizations. The study aimed to determine if patients identified as high‐risk by the S2PLIT‐UG score have higher circulating levels of biomarkers associated with poor prognosis such as soluble suppressor of tumorigenicity 2 (ssT2), high‐sensitivity cardiac troponin I (hs‐cTnI) and N‐terminal pro b‐type natriuretic peptide (NT‐proBNP). A secondary aim was to examine correlations of the S2PLIT‐UG score with the aforementioned biomarkers. Methods: A new validation cohort consisting of 96 patients hospitalized for ADHF and without acute coronary syndrome as an underlying culprit were consecutively included in the study during 2018‐2019. All patients underwent standard transthoracic echocardiography, laboratory analyses of peripheral blood, and had their S2PLIT‐UG score calculated with a high‐risk score being defined as having ≥4 points. Results: One‐quarter of patients (25%, N=24) in analyzed cohort were identified as a high‐risk while 75% of patients (N=72) were non‐high risk according to the S2PLIT‐UG stratification system. Out of those designated as non‐high risk, vast majority were low risk (70.8%, N=51) and 29.2% (N=21) were intermediate risk. High risk group did not significantly differ from non‐high risk group of patients in terms of baseline characteristics including age (p=0.161), body mass index (p=0.437), sex distribution (p=0.637), smoking (p=0.626), dyslipidemia (p=0.898), diabetes mellitus (p=0.286) and presence of atrial fibrillation (p=0.288). Patients identified as high risk had significantly higher circulating levels of ssT2 (65.2±50.2 vs. 34.8±26.4 ng/mL, p<0.001), hs‐ cTnI (142.2±239.0 vs. 42.9±94.0 ng/L, p=0.006), and NT‐proBNP (13199±15325 vs. 5189±7295 pg/mL, p=0.001), compared to patients designated as non‐high risk (Figure 1). As a continuous variable, the S2PLIT‐UG score was in positive and significant correlation with circulating levels of ssT2 (Pearson's r=0.420, p<0.001), hs‐cTnI (r=0.281, p=0.007), and NT‐proBNP (r=0.344, p=0.001). Conclusions: A present study demonstrated that patients identified as high‐risk according to S2PLIT‐UG score had significantly higher circulating levels of biomarkers associated with poor prognosis, compared to non‐high risk patients while S2PLIT‐UG score correlated positively and significantly with circulating levels of ssT2, hs‐cTnI and NT‐proBNP. These findings suggest a possible complementary value of the S2PLIT‐UG score in the risk stratification of ADHF patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
HFA Discoveries 2020 Abstract



POVEZANOST RADA


Ustanove:
KBC Split,
Medicinski fakultet, Split,
Sveučilište u Splitu

Citiraj ovu publikaciju

(CATSTAT-HF) Borovac, Josip Anđelo; D'Amario, Domenico; Glavaš, Duška; Sušilović Grabovac, Zora; Šupe Domić, Daniela; Novak, Katarina; Bradarić, Anteo; Miličić, Davor; Duplančić, Darko; Božić, Joško
P267 The S2PLIT-UG score, a novel system identifying patients with a high risk of all- cause mortality following acute decompensation of heart failure, correlates with levels of sST2, hs-cTnI and NT-proBNP // European Journal of Heart Failure, 22 (2020), S1; 27-28 doi:10.1002/ejhf.1963 (međunarodna recenzija, ostalo)
(CATSTAT-HF) (CATSTAT-HF) Borovac, J., D'Amario, D., Glavaš, D., Sušilović Grabovac, Z., Šupe Domić, D., Novak, K., Bradarić, A., Miličić, D., Duplančić, D. & Božić, J. (2020) P267 The S2PLIT-UG score, a novel system identifying patients with a high risk of all- cause mortality following acute decompensation of heart failure, correlates with levels of sST2, hs-cTnI and NT-proBNP. European Journal of Heart Failure, 22 (S1), 27-28 doi:10.1002/ejhf.1963.
@article{article, year = {2020}, pages = {27-28}, DOI = {10.1002/ejhf.1963}, keywords = {S2PLIT-UG score, inflammation, adverse, ventricular remodeling, fibrosis, ventricular dysfunction, LV, sST2, hs-cTnI, myocardial injury, troponin, soluble suppression of tumorigenicity 2, NT-proBNP, natriuretic peptides}, journal = {European Journal of Heart Failure}, doi = {10.1002/ejhf.1963}, volume = {22}, number = {S1}, issn = {1388-9842}, title = {P267 The S2PLIT-UG score, a novel system identifying patients with a high risk of all- cause mortality following acute decompensation of heart failure, correlates with levels of sST2, hs-cTnI and NT-proBNP}, keyword = {S2PLIT-UG score, inflammation, adverse, ventricular remodeling, fibrosis, ventricular dysfunction, LV, sST2, hs-cTnI, myocardial injury, troponin, soluble suppression of tumorigenicity 2, NT-proBNP, natriuretic peptides} }
@article{article, year = {2020}, pages = {27-28}, DOI = {10.1002/ejhf.1963}, keywords = {S2PLIT-UG score, inflammation, adverse, ventricular remodeling, fibrosis, ventricular dysfunction, LV, sST2, hs-cTnI, myocardial injury, troponin, soluble suppression of tumorigenicity 2, NT-proBNP, natriuretic peptides}, journal = {European Journal of Heart Failure}, doi = {10.1002/ejhf.1963}, volume = {22}, number = {S1}, issn = {1388-9842}, title = {P267 The S2PLIT-UG score, a novel system identifying patients with a high risk of all- cause mortality following acute decompensation of heart failure, correlates with levels of sST2, hs-cTnI and NT-proBNP}, keyword = {S2PLIT-UG score, inflammation, adverse, ventricular remodeling, fibrosis, ventricular dysfunction, LV, sST2, hs-cTnI, myocardial injury, troponin, soluble suppression of tumorigenicity 2, NT-proBNP, natriuretic peptides} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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