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Pregled bibliografske jedinice broj: 1076990

Simple and Rapid Micellar Electrokinetic Chromatography Method for Simultaneous Determination of Febuxostat and its Related Impurities


Sertić, Miranda; Mornar, Ana; Nigović, Biljana
Simple and Rapid Micellar Electrokinetic Chromatography Method for Simultaneous Determination of Febuxostat and its Related Impurities // Chromatographia, 83 (2020), 993-1000 doi:10.1007/s10337-020-03919-7 (međunarodna recenzija, članak, znanstveni)


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Naslov
Simple and Rapid Micellar Electrokinetic Chromatography Method for Simultaneous Determination of Febuxostat and its Related Impurities

Autori
Sertić, Miranda ; Mornar, Ana ; Nigović, Biljana

Izvornik
Chromatographia (0009-5893) 83 (2020); 993-1000

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Capillary electrophoresis · Febuxostat · Micellar electrokinetic chromatography · Pharmaceuticals · Related substances

Sažetak
A micellar electrokinetic capillary chromatography (MEKC) method has been developed and validated for simultaneous analysis of febuxostat and its related substances in active pharmaceutical ingredients and pharmaceutical formulations. Analysis was performed in an uncoated fused silica capillary (34 cm effective length, 50 μm diameter). Method sensitivity was enhanced using an extended light path capillary, with an optical path 150 μm and the choice of 320 nm detector operat-ing wavelength due to lower background noise and higher selectivity. BGE consisted of 20 mM borate buffer pH 9.3 and 50 mM SDS and 2% acetonitrile. Analysis was performed at 30 kV separation voltage and 32 °C capillary temperature. The method was linear over the range 1.0–10.0 μg mL−1 for each impurity corresponding to reporting limits regarding the ICH Q3A guidelines. The method has proven to be selective, precise, accurate and robust. Proposed MEKC method has been successfully applied for the quantitative determination of febuxostat and purity assay of active pharmaceutical ingredient and tablet dosage forms.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Miranda Sertić (autor)

Avatar Url Biljana Nigović (autor)

Avatar Url Ana Mornar Turk (autor)

Citiraj ovu publikaciju

Sertić, Miranda; Mornar, Ana; Nigović, Biljana
Simple and Rapid Micellar Electrokinetic Chromatography Method for Simultaneous Determination of Febuxostat and its Related Impurities // Chromatographia, 83 (2020), 993-1000 doi:10.1007/s10337-020-03919-7 (međunarodna recenzija, članak, znanstveni)
Sertić, M., Mornar, A. & Nigović, B. (2020) Simple and Rapid Micellar Electrokinetic Chromatography Method for Simultaneous Determination of Febuxostat and its Related Impurities. Chromatographia, 83, 993-1000 doi:10.1007/s10337-020-03919-7.
@article{article, year = {2020}, pages = {993-1000}, DOI = {10.1007/s10337-020-03919-7}, keywords = {Capillary electrophoresis · Febuxostat · Micellar electrokinetic chromatography · Pharmaceuticals · Related substances}, journal = {Chromatographia}, doi = {10.1007/s10337-020-03919-7}, volume = {83}, issn = {0009-5893}, title = {Simple and Rapid Micellar Electrokinetic Chromatography Method for Simultaneous Determination of Febuxostat and its Related Impurities}, keyword = {Capillary electrophoresis · Febuxostat · Micellar electrokinetic chromatography · Pharmaceuticals · Related substances} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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