Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1075410

Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers


Borovac, Josip Anđelo; D'Amario, Domenico; Bozic, Josko; Glavas, Duska
Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers // World Journal of Cardiology, 12 (2020), 8; 373-408 doi:10.4330/wjc.v12.i8.373 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1075410 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers

Autori
Borovac, Josip Anđelo ; D'Amario, Domenico ; Bozic, Josko ; Glavas, Duska

Izvornik
World Journal of Cardiology (1949-8462) 12 (2020), 8; 373-408

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Autonomic nervous system ; Biomarkers ; Catecholamines ; Catestatin ; Chromaffin system ; Epinephrine ; Heart failure ; Myocardial failure ; Norepinephrine ; Sympathetic nervous system

Sažetak
Heart failure (HF) is a complex clinical syndrome characterized by the activation of at least several neurohumoral pathways that have a common role in maintaining cardiac output and adequate perfusion pressure of target organs and tissues. The sympathetic nervous system (SNS) is upregulated in HF as evident in dysfunctional baroreceptor and chemoreceptor reflexes, circulating and neuronal catecholamine spillover, attenuated parasympathetic response, and augmented sympathetic outflow to the heart, kidneys and skeletal muscles. When these sympathoexcitatory effects on the cardiovascular system are sustained chronically they initiate the vicious circle of HF progression and become associated with cardiomyocyte apoptosis, maladaptive ventricular and vascular remodeling, arrhythmogenesis, and poor prognosis in patients with HF. These detrimental effects of SNS activity on outcomes in HF warrant adequate diagnostic and treatment modalities. Therefore, this review summarizes basic physiological concepts about the interaction of SNS with the cardiovascular system and highlights key pathophysiological mechanisms of SNS derangement in HF. Finally, special emphasis in this review is placed on the integrative and up-to-date overview of diagnostic modalities such as SNS imaging methods and novel laboratory biomarkers that could aid in the assessment of the degree of SNS activation and provide reliable prognostic information among patients with HF.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC Split,
Medicinski fakultet, Split,
Sveučilište u Splitu

Citiraj ovu publikaciju

Borovac, Josip Anđelo; D'Amario, Domenico; Bozic, Josko; Glavas, Duska
Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers // World Journal of Cardiology, 12 (2020), 8; 373-408 doi:10.4330/wjc.v12.i8.373 (međunarodna recenzija, pregledni rad, znanstveni)
Borovac, J., D'Amario, D., Bozic, J. & Glavas, D. (2020) Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers. World Journal of Cardiology, 12 (8), 373-408 doi:10.4330/wjc.v12.i8.373.
@article{article, year = {2020}, pages = {373-408}, DOI = {10.4330/wjc.v12.i8.373}, keywords = {Autonomic nervous system, Biomarkers, Catecholamines, Catestatin, Chromaffin system, Epinephrine, Heart failure, Myocardial failure, Norepinephrine, Sympathetic nervous system}, journal = {World Journal of Cardiology}, doi = {10.4330/wjc.v12.i8.373}, volume = {12}, number = {8}, issn = {1949-8462}, title = {Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers}, keyword = {Autonomic nervous system, Biomarkers, Catecholamines, Catestatin, Chromaffin system, Epinephrine, Heart failure, Myocardial failure, Norepinephrine, Sympathetic nervous system} }
@article{article, year = {2020}, pages = {373-408}, DOI = {10.4330/wjc.v12.i8.373}, keywords = {Autonomic nervous system, Biomarkers, Catecholamines, Catestatin, Chromaffin system, Epinephrine, Heart failure, Myocardial failure, Norepinephrine, Sympathetic nervous system}, journal = {World Journal of Cardiology}, doi = {10.4330/wjc.v12.i8.373}, volume = {12}, number = {8}, issn = {1949-8462}, title = {Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers}, keyword = {Autonomic nervous system, Biomarkers, Catecholamines, Catestatin, Chromaffin system, Epinephrine, Heart failure, Myocardial failure, Norepinephrine, Sympathetic nervous system} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font