engleski

Angioscintigraphic analysis of regional circulation disturbances in chronic leg ischemia

The purpose of this investigation was to determinate possibility of non-invasive quantification of regional functional vascular reserve with radiofarmaceuticals in basal conditions and after test of reactive hyperaemia in patients having obliterary artery disease of lower extremities. Study included healthy persons (group A, N=16) and 60 symptomatic patients who underwent complete clinical and diagnostic investigations and were classified according to their diagnosis into three groups: atherosclerosis of lower extremities (group B, N=32), diabetic angiopathy (group C, N=18), thromboangiitis obliterans (group D, N=10). Dynamic and blood pool scintigraphy were performed after in vivo labeled erythrocytes with 99mTc-pirofosfat in basal conditions and after test of reactive hyperemia with blood pressure cuff for each patient. Three scintigraphic parameters were derived from computer analyses in three regions of interest (calf, feet and toes) in each leg. Groups were analyzed according to the following parameters: 1) basal accumulation index (BAI) which presents normalized basal regional count numbers, 2) index of reactive hyperemia (IRH) presents change in regional count numbers during test of reactive hyperemia and 3) retention index (RI) presents normalized delayed regional count numbers.

Angioscintigraphy, regional circulation disturbances, chronic leg ischemia

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