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Pregled bibliografske jedinice broj: 1075145

THE IMPACT OF POSITIVE ANTI-HBc MARKER ON PERMANENT DEFERRAL OF VOLUNTARY BLOOD DONORS IN EASTERN CROATIA AND ESTIMATION OF OCCULT HEPATITIS B VIRUS INFECTION RATE


Samardžija, Marko; Drenjančević, Domagoj; Miletić, Manuela; Slavulj, Blaženka; Jukić, Irena; Zibar, Lada; Mihaljević, Silvio; Ferenc Kiš, Marina; Samardžija, Marina
THE IMPACT OF POSITIVE ANTI-HBc MARKER ON PERMANENT DEFERRAL OF VOLUNTARY BLOOD DONORS IN EASTERN CROATIA AND ESTIMATION OF OCCULT HEPATITIS B VIRUS INFECTION RATE // Acta clinica Croatica, 59 (2020), 126-134 doi:10.20471/acc.2020.59.01.15 (domaća recenzija, članak, znanstveni)


CROSBI ID: 1075145 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
THE IMPACT OF POSITIVE ANTI-HBc MARKER ON PERMANENT DEFERRAL OF VOLUNTARY BLOOD DONORS IN EASTERN CROATIA AND ESTIMATION OF OCCULT HEPATITIS B VIRUS INFECTION RATE

Autori
Samardžija, Marko ; Drenjančević, Domagoj ; Miletić, Manuela ; Slavulj, Blaženka ; Jukić, Irena ; Zibar, Lada ; Mihaljević, Silvio ; Ferenc Kiš, Marina ; Samardžija, Marina

Izvornik
Acta clinica Croatica (0353-9466) 59 (2020); 126-134

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Blood donors ; Hepatitis B ; Hepatitis B virus ; Hepatitis B surface antigen ; Croatia

Sažetak
SUMMARY – Recently an increase has been reported in the number of HBV transmissions from anti-HBc positive blood donors that were repeatedly negative in HBsAg and nucleic acid testing using the most sensitive tests available. The aim of the study was to show the effect of anti-HBc antibody testing performed in 2006 on permanent deferral of voluntary blood donors (VBDs), and to estimate occult hepatitis B infection (OBI) rate in this population after the introduction of mandatory molecular testing in the 2013-2016 period. More than 30, 000 blood donations collected during the 2005-2007 period and more than 14, 000 VBDs having donated blood during the 2013-2016 period after the introduction of molecular testing from eastern Croatia were included in the study. Serologic testing was performed with HBsAg assay throughout the study period, and anti-HBc assay was only performed in 2006. As part of the confirmatory algorithm testing, all HBsAg positive and unclear results were tested with molecular tests. Anti-HBc prevalence among VBDs in 2006 was 1.5%, with a rate of 1:197, whereas HBsAg prevalence was stable from 2005 to 2007 (0.04%, 0.1% and 0.1%, respectively). The calculated OBI rate from 2013 to 2016 was 1:30, 250. Ten of 161 (12.4%) VBDs had serologic anti-HBc-only pattern. Anti-HBc testing in 2006 resulted in statistically more deferrals of VBDs compared to 2005 and 2007, and to the rest of Republic of Croatia. The strategy of universal anti-HBc testing of VBDs in addition to the existing HBsAg and molecular screening could be an additional measure to prevent HBV transmission by blood and blood components.

Izvorni jezik
Engleski



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Citiraj ovu publikaciju:

Samardžija, Marko; Drenjančević, Domagoj; Miletić, Manuela; Slavulj, Blaženka; Jukić, Irena; Zibar, Lada; Mihaljević, Silvio; Ferenc Kiš, Marina; Samardžija, Marina
THE IMPACT OF POSITIVE ANTI-HBc MARKER ON PERMANENT DEFERRAL OF VOLUNTARY BLOOD DONORS IN EASTERN CROATIA AND ESTIMATION OF OCCULT HEPATITIS B VIRUS INFECTION RATE // Acta clinica Croatica, 59 (2020), 126-134 doi:10.20471/acc.2020.59.01.15 (domaća recenzija, članak, znanstveni)
Samardžija, M., Drenjančević, D., Miletić, M., Slavulj, B., Jukić, I., Zibar, L., Mihaljević, S., Ferenc Kiš, M. & Samardžija, M. (2020) THE IMPACT OF POSITIVE ANTI-HBc MARKER ON PERMANENT DEFERRAL OF VOLUNTARY BLOOD DONORS IN EASTERN CROATIA AND ESTIMATION OF OCCULT HEPATITIS B VIRUS INFECTION RATE. Acta clinica Croatica, 59, 126-134 doi:10.20471/acc.2020.59.01.15.
@article{article, year = {2020}, pages = {126-134}, DOI = {10.20471/acc.2020.59.01.15}, keywords = {Blood donors, Hepatitis B, Hepatitis B virus, Hepatitis B surface antigen, Croatia}, journal = {Acta clinica Croatica}, doi = {10.20471/acc.2020.59.01.15}, volume = {59}, issn = {0353-9466}, title = {THE IMPACT OF POSITIVE ANTI-HBc MARKER ON PERMANENT DEFERRAL OF VOLUNTARY BLOOD DONORS IN EASTERN CROATIA AND ESTIMATION OF OCCULT HEPATITIS B VIRUS INFECTION RATE}, keyword = {Blood donors, Hepatitis B, Hepatitis B virus, Hepatitis B surface antigen, Croatia} }
@article{article, year = {2020}, pages = {126-134}, DOI = {10.20471/acc.2020.59.01.15}, keywords = {Blood donors, Hepatitis B, Hepatitis B virus, Hepatitis B surface antigen, Croatia}, journal = {Acta clinica Croatica}, doi = {10.20471/acc.2020.59.01.15}, volume = {59}, issn = {0353-9466}, title = {THE IMPACT OF POSITIVE ANTI-HBc MARKER ON PERMANENT DEFERRAL OF VOLUNTARY BLOOD DONORS IN EASTERN CROATIA AND ESTIMATION OF OCCULT HEPATITIS B VIRUS INFECTION RATE}, keyword = {Blood donors, Hepatitis B, Hepatitis B virus, Hepatitis B surface antigen, Croatia} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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