Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1074822

Physicochemical Compatibility Investigation of Mesalazine and Folic Acid Using Chromatographic and Thermoanalytical Techniques


Jeličić, Mario-Livio; Brusač, Edvin; Amidžić Klarić, Daniela; Nigović, Biljana; Keser, Sabina; Mornar, Ana
Physicochemical Compatibility Investigation of Mesalazine and Folic Acid Using Chromatographic and Thermoanalytical Techniques // Pharmaceuticals, 13 (2020), 8; 187, 15 doi:10.3390/ph13080187 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1074822 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Physicochemical Compatibility Investigation of Mesalazine and Folic Acid Using Chromatographic and Thermoanalytical Techniques

Autori
Jeličić, Mario-Livio ; Brusač, Edvin ; Amidžić Klarić, Daniela ; Nigović, Biljana ; Keser, Sabina ; Mornar, Ana

Izvornik
Pharmaceuticals (1424-8247) 13 (2020), 8; 187, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mesalazine ; folic acid ; inflammatory bowel disease ; drug compatibility ; fixed-dose combination

Sažetak
Inflammatory bowel disease is a common name for Crohn’s disease and ulcerative colitis. These inflammatory states cause damage in the sidewalls of the gastrointestinal tract, resulting in malabsorption of food and vitamins. Folic acid (Vitamin B9) is often associated with inflammatory bowel diseases since reduced overall folate concentration in the human body may lead to the development of colorectal cancer and megaloblastic anaemia. However, its deficiency is easily compensated by taking an additional folic acid pill during regular therapy. At the moment, there are no studies that have examined the compatibility of folic acid with 5 aminosalicylate drugs used in the treatment of inflammatory bowel diseases. In this work, differential scanning calorimetry, forced degradation studies, isothermal stress testing and dissolution stability testing were used to determine the stability of folic acid and one of the most commonly used 5-aminosalicylates, mesalazine, when present in the same solution or blend. To monitor the assay of folic acid, mesalazine and nine of its related impurities, a single HPLC method was developed. Results of compatibility studies showed that no physicochemical interaction between mesalazine and folic acid occurs when combined, opening the path to the development of new formulations, such as a mesalazine/folic acid fixed-dose combination.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-DOK-2017-01-9047 - HRZZ-DOK-2017-01-9047 (, )
HRZZ-UIP-2017-05-3949 - Razvoj naprednih analitičkih metoda za lijekove i biološki aktivne tvari u liječenju upalnih bolesti crijeva (IBDAnalytics) (Mornar Turk, Ana, HRZZ - 2017-05 )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Citiraj ovu publikaciju

Jeličić, Mario-Livio; Brusač, Edvin; Amidžić Klarić, Daniela; Nigović, Biljana; Keser, Sabina; Mornar, Ana
Physicochemical Compatibility Investigation of Mesalazine and Folic Acid Using Chromatographic and Thermoanalytical Techniques // Pharmaceuticals, 13 (2020), 8; 187, 15 doi:10.3390/ph13080187 (međunarodna recenzija, članak, znanstveni)
Jeličić, M., Brusač, E., Amidžić Klarić, D., Nigović, B., Keser, S. & Mornar, A. (2020) Physicochemical Compatibility Investigation of Mesalazine and Folic Acid Using Chromatographic and Thermoanalytical Techniques. Pharmaceuticals, 13 (8), 187, 15 doi:10.3390/ph13080187.
@article{article, year = {2020}, pages = {15}, DOI = {10.3390/ph13080187}, chapter = {187}, keywords = {mesalazine, folic acid, inflammatory bowel disease, drug compatibility, fixed-dose combination}, journal = {Pharmaceuticals}, doi = {10.3390/ph13080187}, volume = {13}, number = {8}, issn = {1424-8247}, title = {Physicochemical Compatibility Investigation of Mesalazine and Folic Acid Using Chromatographic and Thermoanalytical Techniques}, keyword = {mesalazine, folic acid, inflammatory bowel disease, drug compatibility, fixed-dose combination}, chapternumber = {187} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font