engleski

The bioactivity of titanium-cuttlefish bone- derived hydroxyapatite composites sintered at low temperature

The most limiting features of titanium as a bone substituent are lack of bioactivity and high Young’s modulus. We have prepared titanium- hydroxyapatite (Ti-HAp) composites using titanium hydride as sintering agent to provide titanium sintering at lower temperature and preserve the stability of apatite phase. After low temperature sintering, no hydroxyapatite decomposition was detected. Pure titanium samples sintered in the presence of hydride showed smooth surface indicating good densification at 800 °C. Higher HAp content resulted in decreased density and higher porosity due to the formation of micro- and macro-pores caused by the integration of HAp particles into titanium matrix and titanium hydride decomposition. However, Vickers microhardness test showed increased hardness for Ti-HAp composite with 10% of HAp regarding pure Ti. The bioactivity of Ti-HAp composites evaluated in simulated body fluid significantly improved with HAp content. The presence of HAp has lowered the cytotoxic effect of Ti-based composites on Hek293 cells.

titanium ; carbonated hydroxyapatite ; cuttlefish bone ; bioactivity ; cytotoxicity

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