Hypothyroidism and Nonalcoholic Fatty Liver Disease: Pathophysiological Associations and Therapeutic Implications (CROSBI ID 281700)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Kizivat, Tomislav ; Maric, Ivana ; Mudri, Dunja ; Bilic Curcic, Ines ; Primorac, Dragan ; Smolic, Martina
engleski
Hypothyroidism and Nonalcoholic Fatty Liver Disease: Pathophysiological Associations and Therapeutic Implications
Nonalcoholic fatty liver disease (NAFLD) is a complex clinical entity which can be secondary to many other diseases including hypothyroidism, characterized by lowering of thyroid hormones and increased thyroid stimulating hormone (TSH). A lot of emerging data published recently advocates the hypothesis that hypothyroid induced NAFLD could be a separate clinical entity, even suggesting possible treatment options for NAFLD involving substitution therapy for hypothyroidism along with lifestyle modifications. In addition, a whole new field of research is focused on thyromimetics in NAFLD/NASH treatment, currently in phase 3 clinical trials. In this critical review we summarized epidemiological and pathophysiological evidence linking these two clinical entities and described specific treatment options with the accent on promising new agents in NAFLD treatment, specifically thyroid hormone receptor (THR) agonist and its metabolites.
NAFLD, MAFLD, Hypothyroidism, Metabolic syndrome, Thyromimetics
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Podaci o izdanju
8
2020.
1-7
objavljeno
2310-8819
10.14218/JCTH.2020.00027
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti